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Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment
dc.creator | Bulatović, Mirna Z. | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Bensing, Christian | |
dc.creator | Gomez-Ruiz, Santiago | |
dc.creator | Steinborn, Dirk | |
dc.creator | Schmidt, Harry | |
dc.creator | Mojić, Marija | |
dc.creator | Korac, Aleksandra | |
dc.creator | Golic, Igor | |
dc.creator | Perez-Quintanilla, Damian | |
dc.creator | Momčilović, Miljana | |
dc.creator | Mijatović, Sanja | |
dc.creator | Kaluđerović, Goran N. | |
dc.date.accessioned | 2016-05-23T11:00:33Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1521-3773 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2205 | |
dc.description.abstract | The strong therapeutic potential of an organotin(IV) compound loaded in nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor growth in syngeneic C57BL/6 mice is almost completely abolished. In contrast to apoptosis as the basic mechanism of the anticancer action of numerous chemotherapeutics, the important advantage of this SBA-15pSn mesoporous material is the induction of cell differentiation, an effect unknown for metal-based drugs and nanomaterials alone. This non-aggressive mode of drug action is highly efficient against cancer cells but is in the concentration range used nontoxic for normal tissue. JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the development of the melanocyte-like nonproliferative phenotype of survived cells indicates the extraordinary potential of SBA-15pSn to suppress tumor growth without undesirable compensatory proliferation of malignant cells in response to neighboring cell death. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of Serbia {[}173013]; Ministerio de Economia y Competitividad, Spain {[}CTQ2012-30762] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Angewandte Chemie-International Edition | |
dc.subject | cell differentiation | |
dc.subject | cisplatin | |
dc.subject | drug delivery | |
dc.subject | melanoma | |
dc.subject | nanostructures | |
dc.title | Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Максимовић, Данијела Д.; Момчиловић, Миљана Б.; Мојић, Марија К.; Калуђеровић, Горан Н.; Перез-Qуинтанилла, Дамиан; Голиц, Игор; Корац, Aлександра; Сцхмидт, Харрy; Стеинборн, Дирк; Гомез-Руиз, Сантиаго; Бенсинг, Цхристиан; Мијатовић, Сања A.; Булатовић, Мирна З.; | |
dc.citation.issue | 23 | |
dc.citation.volume | 53 | |
dc.identifier.doi | 10.1002/anie.201400763 | |
dc.identifier.scopus | 2-s2.0-84901706750 | |
dc.identifier.wos | 000337094200046 | |
dc.citation.spage | 5982 | |
dc.citation.epage | 5987 | |
dc.type.version | publishedVersion | en |
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