Metals and electrolytes in sclerotic hippocampi in patients with drug-resistant mesial temporal lobe epilepsy
2014
Аутори:
Ristic, Aleksandar J.Sokic, Dragoslav
Bascarevic, Vladimir
Spasic, Snezana
Vojvodic, Nikola
Savic, Slobodan
Raicevic, Savo
Kovacevic, Masa
Savić, Danijela
Spasojevic, Ivan
Тип документа:
Чланак у часопису (Објављена верзија)
,
Wiley Periodicals, Inc. © 2014 International League Against Epilepsy
Метаподаци
Приказ свих података о документуАпстракт:
An altered metal and electrolyte profile has been implicated in the
pathologic mechanisms of chronic epilepsy; however, no study has
comprehensively measured hippocampal concentrations of these elements in
patients with mesial temporal lobe epilepsy and hippocampal sclerosis
(mTLE-HS). We therefore analyzed hippocampi of 24 patients with
drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior
temporal lobe resection and amygdalohippocampectomy and 17 hippocampi
obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years),
using inductively coupled plasma optical emission spectrometry
(ICP-OES). Epileptic hippocampi showed significantly lower
concentrations (g/g of tissue) of copper (HS: 2.34 +/- 0.12; control
{[}C]: 3.57 +/- 0.33; p<0.001), manganese (HS: 0.205 +/- 0.030; C: 0.409
+/- 0.064; p=0.004), and potassium (HS: 2,001 +/- 59; C: 2,322 +/- 61;
p<0.001), and increased sodium levels (HS: 1,131 +/- 22; C: 1,040 +/-
25; p=0.010). Zinc, iron, calcium, and magnesium levels did not differ
in HS and controls. In summary, copper and manganese levels are
deficient, whereas iron level is unchanged in hippocampi from patients
with mTLE-HS. Our results provide a basis for understanding the
potential involvement of different metals and electrolytes in the
pathology of HS. A PowerPoint slide summarizing this article is
available for download in the Supporting Information section .
Кључне речи:
Mesial temporal epilepsy; Hippocampal sclerosis; Copper; Manganese; ElectrolytesИзвор:
Epilepsia, 2014, 55, 5, E34-E37Финансирање / пројекти:
- Молекуларни механизми редокс сигналинга у хомеостази, адаптацији и патологији (RS-MESTD-Basic Research (BR or ON)-173014)
- Симултана биоремедијација и соилификација деградираних простора, за очување природних ресурса биолошки активних супстанци и развој и производњу биоматеријала и дијететских производа (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
DOI: 10.1111/epi.12593
ISSN: 1528-1167