High-fructose diet leads to visceral adiposity and hypothalamic leptin resistance in male rats - do glucocorticoids play a role?
2014
Аутори:
Bursac, Biljana N.Teofilović, Ana
Nestorović, Nataša
Velickovic, Natasa A.
Vojnović-Milutinović, Danijela
Matić, Gordana
Đorđević, Ana
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Fructose overconsumption has been involved in the genesis and
progression of the metabolic syndrome. Hypothalamus and adipose tissue,
major organs for control of food intake and energy metabolism, play
crucial roles in metabolic homeostasis. We hypothesized that
glucocorticoid signaling mediates the effects of a fructose-enriched
diet on visceral adiposity by acting on neuropeptide Y (NPY) in the
hypothalamus and altering adipogenic transcription factors in the
visceral adipose tissue.
We analyzed the effects of 9-week consumption of 60\% fructose solution
on dyslipidemia, insulin and leptin sensitivity, and adipose tissue
histology in male Wistar rats. Glucocorticoid signaling was assessed in
both hypothalamus and visceral adipose tissue, while the levels of
peroxisome-proliferator-activated receptor gamma (PPAR-gamma), sterol
regulatory element-binding protein-1 (SREBP-1) and lipin-1, together
with the levels of their target genes expression, were analyzed in the
visceral adipose tissue.
The results showed that long-term consumption of highly concentrated
liquid fructose led to the development of visceral adiposity, elevated
triglycerides and hypothalamic leptin resistance accompanied by
stimulated glucocorticoid signaling and NPY mRNA elevation. Results from
adipose tissue implied that fructose consumption shifted the balance
between glucocorticoid receptor and adipogenic transcriptional factors
(PPAR gamma, SREBP-1 and lipin-1) in favor of adipogenesis judged by
distinctly separated populations of small adipocytes observed in this
tissue. In summary, we propose that high-fructose-diet-induced
alterations of glucocorticoid signaling in both hypothalamus and adipose
tissue result in enhanced adipogenesis, possibly serving as an
adaptation to energy excess in order to limit deposition of fat in
nonadipose tissues. (C) 2014 Elsevier Inc. All rights reserved.
Кључне речи:
Fructose; Hypothalamus; Visceral adipose tissue; Leptin; Glucocorticoids; AdipogenesisИзвор:
Journal of Nutritional Biochemistry, 2014, 25, 4, 446-455
DOI: 10.1016/j.jnutbio.2013.12.005
ISSN: 1873-4847