Protective effects of oestradiol against cadmium-induced changes in blood parameters and oxidative damage in rats
2014
Аутори:
Mladenovic, JelenaOgnjanovic, Branka
Đorđević, Natasa
Matic, Milos
Knezevic, Veroljub
Štajn, Andraš Š.
Saičić, Zorica
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The aim of this study was to investigate the protective effects of
oestradiol (E2, 4 mg kg(-1) b.w.i.p.) against cadmium-induced (Cd, 2 mg
kg(-1) b.w. i.p.) blood changes in rats. Cadmium induced a significant
decline in haemoglobin, haematocrit, and total erythrocyte, lymphocyte,
and thrombocyte count, whereas total leukocytes and granulocytes
increased. A significant increase was also observed in serum
cholesterol, triglycerides, glucose, AST, and ALT activities, whereas
total protein and albumin levels dropped significantly. Administration
of E2 in combination with Cd alleviated most of these adverse effects.
In terms of oxidative stress, Cd significantly increased oxygen-free
radicals (O-2-and H2O2) in neutrophils and lipid peroxidation in
erythrocytes, whereas E2 treatment reversed these changes to control
values. Acute Cd poisoning significantly lowered antioxidant enzyme (SOD
and CAT) activity and the level of non-enzymatic antioxidants (GSH and
vitamin E), while increasing in GSSG. Treatments with E2 reversed
Cd-induced effects on the antioxidant defences and significantly lowered
Cd-induced oxidative damage in erythrocytes. This study suggests that
exogenous E2 effectively restores redox balance in rat erythrocytes and
counters adverse haematological and biochemical effects of Cd poisoning.
It also improves the antioxidant capacity of erythrocytes, acting in
synergy with endogenous antioxidants.
Кључне речи:
antioxidant defence system; biochemical parameters; erythrocytes; haematological parameters; heavy metals; oxidative stress; reactive oxygen species; sex hormoneИзвор:
Arhiv za Higijenu Rada I Toksikologiju - Archives of Industrial Hygiene and Toxicology, 2014, 65, 1, 37-46
DOI: 10.2478/10004-1254-65-2014-2405
ISSN: 1848-6312