Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD
2014
Аутори:
Matić, GordanaVojnović-Milutinović, Danijela
Brkljačić, Jelena
Elaković, Ivana
Manitašević Jovanović, Sanja
Elzaedi, Younis Mouftah
Perisic, Tatjana
Dunderski, Jadranka
Damjanovic, Svetozar
Knezevic, Goran
Spiric, Zeljko
Vermetten, Eric
Savic, Danka
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Alterations in the number and functional status of mineralocorticoid
(MR) and glucocorticoid receptors (GR) may contribute to vulnerability
to posttraumatic stress disorder (PTSD). Corticosteroid receptors are
chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations
between corticosteroid receptor and heat shock protein expression
levels, and related them with war trauma exposure, PTSD and resilience
to PTSD. Relative levels of MR. Hsp90 and Hsp70 were determined by
immunoblotting in lymphocytes from war trauma-exposed men with current
PTSD (current PTSD group, n=113), with lifetime PTSD (life-time PTSD
group, n=61) and without PTSD (trauma control group, n=88), and from
non-traumatized healthy controls (healthy control group, n=85).
Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR
ratio were not observed. The level of MR was correlated with both Hsp90
and Hsp70 levels in trauma control and healthy control groups. On the
other hand, GR level was correlated only with Hsp90 level, and this
correlation was evident in current PTSD and trauma control groups. In
conclusion, PTSD and exposure to trauma are not related to changes in
lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with
disturbances in corticosteroid receptors interaction with heat shock
proteins. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Кључне речи:
Mineralocorticoid receptor; Glucocorticoid receptor; Hsp90; Hsp70; War traumaИзвор:
Psychiatry Research, 2014, 215, 2, 379-385
DOI: 10.1016/j.psychres.2013.11.022
ISSN: 0165-1781