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Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD
dc.creator | Matić, Gordana | |
dc.creator | Vojnović-Milutinović, Danijela | |
dc.creator | Brkljačić, Jelena | |
dc.creator | Elaković, Ivana | |
dc.creator | Manitašević Jovanović, Sanja | |
dc.creator | Elzaedi, Younis Mouftah | |
dc.creator | Perisic, Tatjana | |
dc.creator | Dunderski, Jadranka | |
dc.creator | Damjanovic, Svetozar | |
dc.creator | Knezevic, Goran | |
dc.creator | Spiric, Zeljko | |
dc.creator | Vermetten, Eric | |
dc.creator | Savic, Danka | |
dc.date.accessioned | 2016-05-23T11:00:39Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0165-1781 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2244 | |
dc.description.abstract | Alterations in the number and functional status of mineralocorticoid (MR) and glucocorticoid receptors (GR) may contribute to vulnerability to posttraumatic stress disorder (PTSD). Corticosteroid receptors are chaperoned by heat shock proteins Hsp90 and Hsp70. We examined relations between corticosteroid receptor and heat shock protein expression levels, and related them with war trauma exposure, PTSD and resilience to PTSD. Relative levels of MR. Hsp90 and Hsp70 were determined by immunoblotting in lymphocytes from war trauma-exposed men with current PTSD (current PTSD group, n=113), with lifetime PTSD (life-time PTSD group, n=61) and without PTSD (trauma control group, n=88), and from non-traumatized healthy controls (healthy control group, n=85). Between-group differences in MR, Hsp90 and Hsp70 levels and in MR/GR ratio were not observed. The level of MR was correlated with both Hsp90 and Hsp70 levels in trauma control and healthy control groups. On the other hand, GR level was correlated only with Hsp90 level, and this correlation was evident in current PTSD and trauma control groups. In conclusion, PTSD and exposure to trauma are not related to changes in lymphocyte MR, Hsp90 or Hsp70 levels, but may be associated with disturbances in corticosteroid receptors interaction with heat shock proteins. (C) 2013 Elsevier Ireland Ltd. All rights reserved. | en |
dc.description.sponsorship | European Commision {[}INCO-CT-2004-509213]; Ministry of Education, Science and Technological Development of the Republic of Serbia {[}41009, 179018] | en |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Psychiatry Research | |
dc.subject | Mineralocorticoid receptor | |
dc.subject | Glucocorticoid receptor | |
dc.subject | Hsp90 | |
dc.subject | Hsp70 | |
dc.subject | War trauma | |
dc.title | Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Јовановиц, Сања Манитасевиц; Матић, Гордана М.; Војновић-Милутиновић, Данијела; Несторов, Јелена; Елзаеди, Yоунис Моуфтах; Перисиц, Татјана; Дундерски, Јадранка; Дамјановиц, Светозар; Кнезевиц, Горан; Спириц, Зељко; Верметтен, Ериц; Савиц, Данка; Елаковић, Ивана; | |
dc.citation.issue | 2 | |
dc.citation.volume | 215 | |
dc.identifier.doi | 10.1016/j.psychres.2013.11.022 | |
dc.identifier.scopus | 2-s2.0-84893756193 | |
dc.identifier.wos | 000332355800019 | |
dc.citation.spage | 379 | |
dc.citation.epage | 385 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M22 |
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