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Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes
dc.creator | Mijatović, Sanja | |
dc.creator | Bulatović, Mirna Z. | |
dc.creator | Mojić, Marija | |
dc.creator | Stošić-Grujičić, Stanislava | |
dc.creator | Miljković, Đorđe | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Gomez-Ruiz, Santiago | |
dc.creator | Pinkas, Jiri | |
dc.creator | Horacek, Michal | |
dc.creator | Kaluđerović, Goran N. | |
dc.date.accessioned | 2016-05-23T11:00:39Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1872-8561 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2247 | |
dc.description.abstract | The previously known complexes {[}Ti\{(Me2CMe2C)(eta(5)-C5H4)(2)\}Cl-2] (1), {[}Ti\{Me2C(eta(5)-C5H4)(2)\}Cl-2] (2), {[}Ti \{Me2Si(eta(5)-C5H4)(2)\}Cl-2] (4), {[}Ti\{MePhSi(eta(5)-C5H4)(2)\}Cl-2] (5) and {[}Ti\{MePhSi(eta(5)-C5Me4)(2)\}Cl-2] (6) have been prepared following reported procedures. The novel complex {[}Ti\{MePhC(eta(5)-C5H4)(2)\}Cl-2] (3) has been prepared and characterized. The cytotoxic activity of 1-6 has been tested after 72 h on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic activity of complexes 1 and 6 compared to the reference compound ({[}Ti(eta(5)-C5H5)(2)\}Cl-2]). 1 and 6 have also been tested against primary normal mouse keratinocytes and lung fibroblasts. While viability of both type of primary cells was significantly less affected by 1 in comparison to the reference compound {[}Ti(eta(5)-C5H5)(2)Cl-2], compound 6 was completely nontoxic for nonmalignant cells, indicating a potential selectivity of this compound towards cancer cell lines. In addition CFSE staining, cell cycle analysis, AnnexinV-FITC/PI staining, detection of caspase activity and mitochondrial potential showed that 1 and 6 were acting through inhibition of proliferation and subsequent induction of mitochondrial dependent apoptosis in colon cancer cell lines, HCT116 and SW620, which express low sensitivity to cisplatin. Compound 6 was found to be the leading drug in this group since it shows the fastest and most selective anticancer profile. (C) 2013 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | Ministerio de Educacion y Ciencia, Spain {[}CTQ-2011-24346, CTQ-2012-30762]; Ministry of Science and Technological Development of the Republic of Serbia {[}173013]; Grant Agency of the Czech Republic {[}P207/12/2368] | en |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Journal of Organometallic Chemistry | |
dc.subject | Titanocene derivatives | |
dc.subject | Cytotoxicity | |
dc.subject | Primary cells | |
dc.subject | Cell cycle analysis | |
dc.subject | Caspase detection | |
dc.title | Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Калуђеровић, Горан Н.; Хорацек, Мицхал; Миљковић, Ђорђе М.; Булатовић, Мирна З.; Мијатовић, Сања A.; Пинкас, Јири; Гомез-Руиз, Сантиаго; Стошић-Грујичић, Станислава Д.; Максимовић, Данијела Д.; Мојић, Марија К.; | |
dc.rights.holder | © 2013 Elsevier B.V. | |
dc.citation.volume | 751 | |
dc.identifier.doi | 10.1016/j.jorganchem.2013.07.059 | |
dc.identifier.scopus | 2-s2.0-84893784744 | |
dc.identifier.wos | 000329864700031 | |
dc.citation.spage | 361 | |
dc.citation.epage | 367 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |