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Bioactive composition, antimicrobial activities and the influence of Agrocybe aegerita (Brig.) Sing on certain quorum-sensing-regulated functions and biofilm formation by Pseudomonas aeruginosa
dc.creator | Petrović, Jovana | |
dc.creator | Glamočlija, Jasmina | |
dc.creator | Stojković, Dejan | |
dc.creator | Nikolić, Miloš | |
dc.creator | Ćirić, Ana | |
dc.creator | Fernandes, Angela | |
dc.creator | Ferreira, Isabel C. F. R. | |
dc.creator | Soković, Marina | |
dc.date.accessioned | 2016-05-23T11:00:42Z | |
dc.date.available | 2016-05-23T11:00:42Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2042-650X | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2267 | |
dc.description.abstract | Agrocybe aegerita (Brig.) Sing is a basidiomycete, white rot fungus. Antimicrobial activities and the antiqourum effect on Pseudomonas aeruginosa of an A. aegerita methanolic extract were investigated. The extract showed very good antimicrobial activity against all the tested microorganisms in a dose dependent manner. Effects of the Sub-MIC, MIC and 2MIC of the A. aegerita methanolic extract regulated the virulence factors in the quorum sensing (QS) test, as well as biofilm formation on P. aeruginosa. Sub-inhibitory and inhibitory concentrations of the extract demonstrated the reduction of virulence factors such as pyocyanin production, twitching and swimming motility. The biofilm forming capability of P. aeruginosa PAO1 was also reduced in a concentration-dependent manner. Furthermore, the chemical composition of the methanolic extract was determined considering its phenolic composition. The methanolic extract of A. aegerita can be a very good source of bioactive substances. This research is of great importance due to the prevalence of drug-resistant microorganisms. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of Serbia {[}173032]; Foundation for Science and Technology (FCT, Portugal) {[}SFRH/BD/76019/2011] | |
dc.language | English | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS// | |
dc.relation | Foundation for Science and Technology (SFRH/BD/76019/2011) | |
dc.rights | restrictedAccess | |
dc.source | Food & Function | |
dc.title | Bioactive composition, antimicrobial activities and the influence of Agrocybe aegerita (Brig.) Sing on certain quorum-sensing-regulated functions and biofilm formation by Pseudomonas aeruginosa | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Фернандес, Aнгела; Ферреира, Исабел Ц. Ф. Р.; Петровиц, Јована; Стојковиц, Дејан; Гламочлија, Јасмина; Николиц, Милос; Ћирић, Aна Д.; Соковић, Марина Д.; | |
dc.rights.holder | © 2014 Royal Society of Chemistry | |
dc.citation.issue | 12 | |
dc.citation.volume | 5 | |
dc.identifier.doi | 10.1039/c4fo00819g | |
dc.identifier.scopus | 2-s2.0-84912063407 | |
dc.identifier.wos | 000345454700027 | |
dc.citation.spage | 3296 | |
dc.citation.epage | 3303 | |
dc.type.version | publishedVersion | en |
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