Comparative phylogenetic analysis of Dobrava-Belgrade virus L and S genetic segments isolated from an animal reservoir in Serbia
2014
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Authors:
Nikolić, ValentinaStajković, N.
Stamenković, Gorana
Cekanac, R.
Marušić, P.
Jovanović, N.
Krstić, Milena
Mladenović, J.
Šiljić, Marina
Gligić, Ana
Stanojević, Maja
Document Type:
Article (Published version)
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Show full item recordAbstract:
The Dobrava-Belgrade virus (DOBV) is a member of the Bunyaviridae
family, genus Hantavirus, possessing a single-stranded RNA genome
consisting of three segments, designated L (large), M (medium) and S
(small). In this study, we present phylogenetic analysis of a newly
detected DOBV strain isolated from Apodemus agrarius. Analysis was based
on partial L and S segment sequences, in comparison to previously
published DOBV sequences from Serbia and elsewhere. A phylogenetic tree
based on partial S segment revealed local geographical clustering of
DOBV sequences from Serbia, unrelated to host (rodent or human). The
topology of the phylogenetic tree was confirmed with a high percent of
completely or partially resolved quartets in likelihood-mapping
analysis, whereas no evidence of possible recombination in the examined
S segment data set was found.
Keywords:
phylogenetic analysis; likelihood mapping; recombinationSource:
Archives of Biological Sciences, 2014, 66, 2, 497-506
DOI: 10.2298/ABS1402497N
ISSN: 1821-4339