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Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats
dc.creator | Vojnović-Milutinović, Danijela | |
dc.creator | Radovanović, Marina | |
dc.creator | Dinic, Jovana | |
dc.creator | Đorđević, Ana | |
dc.creator | Velickovic, Natasa | |
dc.creator | Elaković, Ivana | |
dc.creator | Matić, Gordana | |
dc.creator | Brkljačić, Jelena | |
dc.date.accessioned | 2016-05-23T11:00:43Z | |
dc.date.available | 2016-05-23T11:00:43Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1821-4339 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2273 | |
dc.description.abstract | Alterations in leptin and glucocorticoid signaling pathways in the hypothalamus of male and female rats subjected to a fructose-enriched diet were studied. The level of expression of the key components of the leptin signaling pathway (neuropeptide Y /NPY/ and suppressor of cytokine signaling 3 /SOCS3/), and the glucocorticoid signaling pathway (glucocorticoid receptor /GR/, 11 beta-hydroxysteroid dehydrogenase type 1 /11 beta HSD1/ and hexose-6-phosphate dehydrogenase /H6PDH/) did not differ between fructose-fed rats and control animals of both genders. However, in females, a fructose-enriched diet provoked increases in the adiposity index, plasma leptin and triglyceride concentrations, and displayed a tendency to decrease the leptin receptor (ObRb) protein and mRNA levels. In male rats, the fructose diet caused elevations in plasma non-esterified fatty acids and triglycerides, as well as in both plasma and hypothalamic leptin concentrations. Our results suggest that a fructose-enriched diet can induce hyperleptinemia in both female and male rats, but with a more pronounced effect on hypothalamic leptin sensitivity in females, probably contributing to the observed development of visceral adiposity. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the Republic of Serbia {[}III41009] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Archives of Biological Sciences | |
dc.subject | Fructose diet | |
dc.subject | hypothalamus | |
dc.subject | leptin | |
dc.subject | leptin receptor | |
dc.subject | glucocorticoids | |
dc.subject | glucocorticoid receptor | |
dc.title | Leptin and glucocorticoid signaling pathways in the hypothalamus of female and male fructose-fed rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ђорђевић, Aна Д.; Велицковиц, Натаса; Матић, Гордана М.; Елаковић, Ивана; Несторов, Јелена; Војновић-Милутиновић, Данијела; Диниц, Јована; Николиц, Марина; | |
dc.citation.issue | 2 | |
dc.citation.volume | 66 | |
dc.identifier.doi | 10.2298/ABS1402829M | |
dc.identifier.scopus | 2-s2.0-84903981177 | |
dc.identifier.wos | 000342265800042 | |
dc.citation.spage | 829 | |
dc.citation.epage | 839 | |
dc.type.version | publishedVersion | en |
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