Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa
2014
Autori:
Pejin, BorisTalevska, Aleksandra
Ćirić, Ana
Glamočlija, Jasmina
Nikolić, Miloš
Talevski, Trajce
Soković, Marina
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The anti-quorum sensing activities towards the bacterium Pseudomonas
aeruginosa PA01 (pyocyanin production, biofilm formation and twitching
and flagella motility) of two crude extracts (methanol and acetone) of
the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) were
evaluated in vitro for the first time. Both extracts demonstrated P.
aeruginosa pyocyanin inhibitory activity, reducing its production for
49.90\% and 42.44\%, respectively. In addition, they both showed higher
anti-biofilm activity (48.29\% and 53.99\%, respectively) than
ampicillin (30.84\%). Finally, O. rotunda extracts effectively reduced
twitching and flagella motility of P. aeruginosa. Taken all together,
these results suggest that endemic sponge species from the oldest lake
in Europe may offer novel bioactive natural products with promising
medicinal potential towards P. aeruginosa infections.
Ključne reči:
Lake Ohrid; Porifera; Ochridaspongia rotunda; bioactivityIzvor:
Natural Product Research, 2014, 28, 24, 2330-2333
DOI: 10.1080/14786419.2014.934239
ISSN: 1478-6427