Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol
2014
Аутори:
Pejin, BorisIodice, Carmine
Tommonaro, Giuseppina
Stanimirovic, Bojana
Ćirić, Ana
Glamočlija, Jasmina
Nikolić, Miloš
De Rosa, Salvatore
Soković, Marina
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
This work extends in vitro screening of antimicrobial activity of the
sesquiterpene hydroquinone avarol, a main secondary metabolite of the
Mediterranean sponge species Dysidea avara. The antimicrobial activity
was in part evaluated by microdilution method against selected bacterial
and fungal strains. Additionally, the screening included evaluation of
anti-quorum sensing (anti-QS) effects. At a different extent avarol was
proven to be active against all the microorganisms tested (MIC
0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and
MFC 0.008-0.030 mg/mL; respectively). This marine natural product also
showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1
biofilm formation (75\%), its twitching and protrusions motilities as
well as pyocianin production (39\%). According to the best of our
knowledge, this is the first report both on avarol anti Gram-negative
bacterial activity and anti-QS effects.