In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937)
2014
Аутори:
Pejin, BorisTalevski, Aleksandra
Ćirić, Ana
Glamočlija, Jasmina
Nikolić, Miloš
Talevski, Trajce
Soković, Marina
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The antimicrobial activity of five crude extracts (aqueous, methanol,
ethyl acetate, acetone and methylene chloride) of the freshwater sponge
Ochridaspongia rotunda (Arndt, 1937) was evaluated in vitro by using
microdilution method against eight bacterial and eight fungal strains
for the first time. The extracts were proven to be active in varying
degrees against all the bacteria and fungi tested. O. rotunda methanol
extract exhibited the highest antibacterial activity (minimum inhibitory
concentration (MIC) 7.5-15.0 mu g/mL and minimum bactericidal
concentration 15-30 mu g/mL), while its acetone extract exhibited the
most promising antifungal activity (MIC 7.5-45.0 mu g/mL and minimum
fungicidal concentration 15-60 mu g/mL). The extracts were more
effective against the bacteria and fungi screened compared with the
positive controls (streptomycin and ampicillin for bacteria and
bifonazole and ketoconazole for fungi, respectively). According to the
experimental data obtained, this deepwater sponge species may be
considered as a gold mine of new antimicrobial substances with
significant and broad-range activity.
Кључне речи:
Porifera; endemic species; Ohrid; extracts; bacteria; fungiИзвор:
Natural Product Research, 2014, 28, 18, 1489-1494
DOI: 10.1080/14786419.2014.911297
ISSN: 1478-6427