Soy extract-dependent changes in morphofunctional parameters of the pituitary corticotropes in adult rats
2014
Аутори:
Trifunović, SvetlanaManojlović-Stojanoski, Milica
Ajdžanović, Vladimir
Nestorović, Nataša
Ristić, Nataša
Šošić-Jurjević, Branka
Milošević, Verica
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2013 Elsevier GmbH.
Метаподаци
Приказ свих података о документуАпстракт:
Numerous studies have established a link between estrogen levels and
activity of the hypothalamic pituitary adrenal (HPA) system. Considering
the ``weak estrogenic{''} effect of soy isoflavones, this study was
designed to evaluate the influence of soy extract treatment on some
morphofunctional parameters of rat pituitary corticotropes in vivo.
Adult male orchidectomized Wistar rats received estradiol-dipropionate
or soy extract in oil/ethanol solvent subcutaneously for 3 weeks. Both
controls, sham-operated (So) and orchidectomized (Orx) rats, were
injected with solvent, in the same regime. Changes in pituitary volume,
total volume, total number and volume of individual corticotropes were
evaluated stereologically, while ACTH levels were determined
biochemically. In comparison with So rats, estradiol treatment provoked
increases (p < 0.05) of ACTH level (166\%), pituitary weight (167\%) and
volume (102\%), total volume (20\%) and total number of corticotropes
(18\%). In comparison to Orx, following estradiol treatment elevation (p
< 0.05) of ADE level (69\%), pituitary weight (131\%) and volume (82\%),
total (30\%) and individual volume (29\%) of corticotropes was observed.
Soy extract treatment led to enhancement (p < 0.05) of: ACTH level
(28\%), total (25\%) and individual volume (20\%) of corticotropes. It
can be concluded that soy extract acts in a similar way to estradiol,
but the increased activity of corticotropes was weaker. (C) 2013
Elsevier GmbH. All rights reserved.
Кључне речи:
Soy extract; Corticotropes; Rats; StereologyИзвор:
Acta Histochemica, 2014, 116, 5, 717-722
DOI: 10.1016/j.acthis.2013.12.010
ISSN: 1618-0372