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Long-term effects of somatostatin 14 on the pituitary-ovarian axis in rats
dc.creator | Nestorović, Nataša | |
dc.creator | Manojlović-Stojanoski, Milica | |
dc.creator | Trifunović, Svetlana | |
dc.creator | Ristić, Nataša | |
dc.creator | Filipović, Branko | |
dc.creator | Šošić-Jurjević, Branka | |
dc.creator | Milošević, Verica | |
dc.date.accessioned | 2016-05-23T11:00:46Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0231-5882 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2287 | |
dc.description.abstract | The long-term effects of somatostatin 14 (SST-14) on the pituitary-ovarian axis were examined. Female Wistar rats received 20 mu g/100 g b.w. doses subcutaneously twice daily for 5 consecutive days in the infantile (from 1lth to 15th day) or peripubertal (from 33rd to 37th day) period of life. Females treated as infants were killed in the peripubertal (38th day) or adult period of life (80th day), and those treated during peripuberty as adults (80th day). Pituitary follicle-stimulating (FSH), luteinizing (LH) and somatotropic (GH) cells, and ovaries were analyzed by stereology and morphometry. Serum FSH and LH concentrations were determined by RTA. FSH and LH cell volumes were significantly decreased in pituitaries of peripubertal females treated with SST-14 as infants, and in adult females treated during peripuberty. GH cell volume was decreased in all treated rats. In the ovaries, enlargement of the non-growing pool of follicles was detected in adult females treated during peripuberty. SST-14 applied to infant rats did not lead to changes in initial follicular recruitment, but it disturbed follicle growth and development at later stages. It can be concluded that SST-14 exerted long-term inhibitory effects on the pituitary-ovarian axis and GH cells in rats. | en |
dc.description.sponsorship | Ministry for Science of Serbia {[}173009] | |
dc.language | English | |
dc.publisher | Bratislava: Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences | |
dc.rights | restrictedAccess | |
dc.source | General Physiology and Biophysics | |
dc.subject | Gonadotropic cells | |
dc.subject | Somatotropic cells | |
dc.subject | Ovary | |
dc.subject | Folliculogenesis | |
dc.subject | Stereology | |
dc.title | Long-term effects of somatostatin 14 on the pituitary-ovarian axis in rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ристиц, Натаса М.; Трифуновиц, Светлана Л.; Милосевиц, Верица Љ.; Филиповић, Бранко; Шошић-Јурјевић, Бранка Т.; Манојловић-Стојаноски, Милица; Несторовић, Наташа М.; | |
dc.rights.holder | © 2014 by the Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences | |
dc.citation.issue | 2 | |
dc.citation.volume | 33 | |
dc.identifier.doi | 10.4149/gpb_2014001 | |
dc.identifier.scopus | 2-s2.0-84904887224 | |
dc.identifier.wos | 000336512200002 | |
dc.citation.spage | 157 | |
dc.citation.epage | 168 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 |