Undecylprodigiosin conjugated monodisperse gold nanoparticles efficiently cause apoptosis in colon cancer cells in vitro
2014
Аутори:
Nikodinovic-Runic, JasminaMojić, Marija
Kang, Yijin
Maksimović-Ivanić, Danijela
Mijatović, Sanja
Vasiljevic, Branka
Stamenkovic, Vojislav R.
Senerovic, Lidija
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Bacterial pigment undecylprodigiosin (UP) was produced using
Streptomyces sp. JS520 and conjugated to monodisperse gold nanoparticles
(UP-Au). Both UP and UP-Au showed cytocidal activity towards melanoma
(A375), lung carcinoma (A549), breast cancer (MCF-7) and colon cancer
(HCT-116) cells, inducing apoptosis with IC50 values ranging from 0.4 to
4 mu g ml(-1). Unconjugated UP had a tendency to lose its activity over
time and to change biophysical characteristics over pH. The loss of the
pigment potency was overcome by conjugation with gold nanoparticles.
UP-Au exhibited high stability over pH 3.8 to 7.4 and its activity
remained unaffected in time. Nano-packing changed the mechanism of UP
toxicity by converting the intracellular signals from a mitochondrial
dependent to a mitochondrial independent apoptotic process. The
availability of nonpyrogenic UP in high amounts, together with specific
anticancer activity and improved stability in the complex with gold
nanoparticles, presents a novel platform for further development of
UP-Au complexes as an anticancer drug suitable for clinical
applications.
Извор:
Journal of Materials Chemistry B, 2014, 2, 21, 3271-3281
DOI: 10.1039/c4tb00300d
ISSN: 2050-7518