Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts of Laurus nobilis L. from Different Origins
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2014
Authors:
Dias, Maria InesBarreira, Joao C. M.
Calhelha, Ricardo C.
Queiroz, Maria-Joao R. P.
Oliveira, M. Beatriz P. P.
Soković, Marina
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Ferreira, Isabel C. F. R.
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Natural matrices are important sources of new antitumor and
antimicrobial compounds. Species such as Laurus nobilis L. (laurel)
might be used for this purpose, considering its medicinal properties.
Herein, in vitro activity against human tumor cell lines, bacteria, and
fungi was evaluated in enriched phenolic extracts. Specifically,
methanol and aqueous extracts of wild and cultivated samples of L.
nobilis were compared considering different phenolic groups. Principal
component analysis (PCA) was applied to understand how each extract acts
differentially against specific bacteria, fungi, and selected human
tumor cell lines. In general, the extract type induced the highest
differences in bioactivity of laurel samples. However, from the PCA
biplot, it became clear that wild laurel samples were higher inhibitors
of tumor cell lines (HeLa, MCF7, NCI-H460, and HCT15). HepG2 had the
same response to laurel from wild and cultivated origin. It was also
observed that methanolic extracts tended to have higher antimicrobial
activity, except against A. niger, A. fumigatus, and P. verrucosum. The
differences in bioactivity might be related to the higher phenolic
contents in methanolic extracts. These results allow selecting the
extract type and/or origin with highest antibacterial, antifungal, and
antitumor activity.
Source:
Biomed Research International, 2014, 520464Funding / projects:
- Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-MESTD-Basic Research (BR or ON)-173032)
DOI: 10.1155/2014/520464
ISSN: 2314-6141
PubMed: 24826380