dc.creator | Nikolic, Valentina | |
dc.creator | Stajkovic, Novica | |
dc.creator | Stamenković, Gorana | |
dc.creator | Cekanac, Radovan | |
dc.creator | Marusic, Predrag | |
dc.creator | Siljic, Marina | |
dc.creator | Gligic, Ana | |
dc.creator | Stanojevic, Maja | |
dc.date.accessioned | 2016-05-23T11:00:47Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1567-7257 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2295 | |
dc.description.abstract | Tula hantavirus (TULV) belongs to Bunyaviridae family, with negative
sense RNA genome. Segmented nature of hantaviral genome allows for
genetic reassortment, but the evidence of homologous recombination also
exists. In this study we analyzed TULV sequences isolated in Serbia on
different occasions and from different rodent hosts: 1987 strain from
Microtus subterraneus and 2007 strain from Microtus arvalis.
Phylogenetic analysis of both L and S segment sequences is suggestive of
geographically related clustering, as previously shown for majority of
hantaviruses. Reconstruction of phylogenetic tree for TULV S segment
showed that both sequences from Serbia clustered together with sequences
from East Slovakia, which had previously been shown to be recombinants
(Kosice strain). Exploratory recombination analysis, supported by
phylogenetic and amino acid pattern analysis, revealed the presence of
recombination in the S segment sequences from Serbia, resulting in
mosaic-like structure of TULV S segment similar to the one of Kosice
strain. Although recombination is considered a rare event in molecular
evolution of negative strand RNA viruses, obtained molecular data in
this study support evidence of recombination in TULV, in geographically
distant regions of Europe. (C) 2013 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | Ministry of Education and Science Republic of Serbia {[}175024] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Infection Genetics and Evolution | |
dc.subject | Recombination | |
dc.subject | Tula virus | |
dc.subject | Phylogenetic analysis | |
dc.subject | Molecular evolution | |
dc.title | Evidence of recombination in Tula virus strains from Serbia | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Цеканац, Радован; Стајковиц, Новица; Марусиц, Предраг; Станојевиц, Маја; Стаменковић, Горана; Николиц, Валентина; Глигиц, Aна; Сиљиц, Марина; Евиденце оф рецомбинатион ин Тула вирус страинс фром Сербиа; | |
dc.citation.volume | 21 | |
dc.identifier.doi | 10.1016/j.meegid.2013.08.020 | |
dc.identifier.scopus | 2-s2.0-84893774623 | |
dc.identifier.wos | 000332273800056 | |
dc.citation.spage | 472 | |
dc.citation.epage | 478 | |
dc.type.version | publishedVersion | en |