Differential effects of cadmium administration on peripheral blood granulocytes in rats
2014
Authors:
Djokic, J.Ninkov, Marina
Mirkov, Ivana
Popov Aleksandrov, Aleksandra
Zolotarevski, L.
Kataranovski, Dragan S.
Kataranovski, Milena
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Infiltration of circulatory inflammatory cells is a common
histopathological finding in target organs following cadmium
administration, but there is paucity of data concerning their activity.
In this study, the effects of sublethal (1 mg/kg) cadmium on peripheral
blood polymorphonuclear (PMN) cells were examined 48 h following
administration in rats, when tissue (liver and lung) infiltration of
these cells was observed. Cadmium administration resulted in systemic
inflammatory cytokine and acute phase response with an increase in
circulatory neutrophil numbers and cells that express CD11b molecules.
Rise in basic aspects of oxidative activity including intracellular
myeloperoxidase (MPO), reactive oxygen (nitroblue tetrazolium/NBT
cytochemical assay) and nitrogen (Griess assay) species production was
observed in PMNs from cadmium-administered rats. A decrease in levels of
mRNA for IL-1 beta, TNF-alpha and IL-6 was noted, but production of
these cytokines was affected differentially. Described effects of
cadmium on PMNs add further to the understanding of inflammatory
potential of this environmental contaminant. (C) 2013 Elsevier B.V. All
rights reserved.
Keywords:
Intraperitoneal cadmium administration; Rat; Systemic inflammatory cytokine and acute phase response; Peripheral blood polymorphonuclear leukocyte (PMN); Oxidative activity; Inflammatory cytokines (IL-1 beta, TNF-alpha, IL-6)Source:
Environmental Toxicology and Pharmacology, 2014, 37, 1, 210-219
DOI: 10.1016/j.etap.2013.11.026
ISSN: 1872-7077