Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils
2014
Аутори:
Nikolić, MilošGlamočlija, Jasmina
Ferreira, Isabel C. F. R.
Calhelha, Ricardo C.
Fernandes, Angela
Markovic, Tatjana
Markovic, Dejan
Giweli, Abdulhamed
Soković, Marina
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2013 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт:
Aromatic plant species of genus Thymus are important medicinal plants,
highly recommended due to a range of therapeutic properties of their
essential oils, commonly known as thyme oil: antirheumatic, antiseptic,
antispasmodic, antimicrobial, cardiac, carminative, diuretic and
expectorant. The oil is also beneficial in boosting the immune system
and helps to fight colds, flu, infectious diseases and chills. It is
proved to be a urinary antiseptic, being very helpful for cystitis and
urethritis. Scientific validation of traditional uses, and phytochemical
and bioactivity evaluation of essential oils from Thymus serpyllum,
Thymus algeriensis and Thymus vulgaris were performed.
GC/MS analysis revealed thymol as a major component of T. algeriensis,
T. vulgaris and T. serpyllum, with its contribution to the oil 56.0\%,
48.9\% and 38.5\%, respectively. All three essential oils (EOs)
exhibited a significant antimicrobial activity against all tested
strains, the T. serpyllum oil being the most potent one (MIC 2.5-5 mu
g/mL, MBC 5-10 mu g/mL; MIC 1-2 mu g/mL, MFC 2-4 mu g/mL). In addition,
the T. serpyllum oil revealed the highest antioxidant activity in all
conducted assays and it was the most effective one against all tested
cell lines, presenting GI(50) values of 7.02-52.69 mu g/mL. Moreover,
none of the EOs showed toxicity at tested concentrations (>400 mu g/mL)
for porcine liver primary cell culture. In addition to their well-known
traditional use in food and cosmetics, the great potential of tested
Thymus essential oils for application in oral diseases and anticancer
treatments, encourage further investigation. (C) 2013 Elsevier B.V. All
rights reserved.
Кључне речи:
T. serpyllum; T. algeriensis; T. vulgaris; Essential oils; Chemical composition; Cytotoxic; Antioxidant; Antimicrobial activityИзвор:
Industrial Crops and Products, 2014, 52, 183-190Финансирање / пројекти:
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)
DOI: 10.1016/j.indcrop.2013.10.006
ISSN: 1872-633X