The effects of estradiol and human chorionic gonadotropin on ACHT cells in peripubertal female rats: A histological and stereological study
2014
Аутори:
Milošević, VericaTodorović, Danijela
Šošić-Jurjević, Branka
Jarić, Ivana
Živanović, Jasmina
Ušćebrka, Gordana
Ajdžanović, Vladimir
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2014 by the Serbian Biological Society
Метаподаци
Приказ свих података о документуАпстракт:
The effects of estradiol (EDP) and human chorionic gonadotropin (HCG) on
histological and stereological features of adrenocorticotropic (ACTH)
cells in peripubertal female rats were examined. The first group of
females received five injections of EDP (0.25 mg/kg b.w.), every second
day from the 4th to 14th day after birth, and was killed at the
peripubertal stage. The second group of females was given two injections
of pregnyl-gonadotrophinum chorionicum (HCG; 50 IU/kg body weight) on
the 36th and 37th days after birth, and it was killed 24 h after the
last treatment. The controls were injected with an equivalent volume of
the corresponding vehicle. ACTH cells were immunohistochemically labeled
and stereologically evaluated. Stereological analysis showed that the
volume of ACTH cells and their volume density in peripubertal females
treated with EDP, were decreased by 15.6\% and 53.8\% (p < 0.05),
respectively, compared to the controls. In HCG-treated animals, the
observed parameters were increased by 39.2\% and 15.4\% (p < 0.05),
respectively, in comparison with the control females. These findings
suggest that the application of EDP or HCG exerted opposite effects on
the stereological features of pituitary ACTH cells.
Кључне речи:
Estradiol; histology; stereologyИзвор:
Archives of Biological Sciences, 2014, 66, 1, 143-148
DOI: 10.2298/ABS1401143M
ISSN: 1821-4339