Influence of the Green Tea Leaf Extract on Neurotoxicity of Aluminium Chloride in Rats
2014
Аутори:
Jelenković, Ankica V.Jovanovic, Marina D.
Stevanovic, Ivana
Petronijevic, Natasa
Bokonjic, Dubravko
Zivkovic, Jelena
Igic, Rajko
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Aluminium may have an important role in the
aetiology/pathogenesis/precipitation of Alzheimer's disease. Because
green tea (Camellia sinensis L.) reportedly has health-promoting effects
in the central nervous system, we evaluated the effects of green tea
leaf extract (GTLE) on aluminium chloride (AlCl3) neurotoxicity in rats.
All solutions were injected into the cornu ammonis region 1 hippocampal
region. We measured the performance of active avoidance (AA) tasks,
various enzyme activities and total glutathione content (TGC) in the
forebrain cortex (FbC), striatum, basal forebrain (BFb), hippocampus,
brain stem and cerebellum. AlCl3 markedly reduced AA performance and
activities of cytochrome c oxidase (COX) and acetylcholinesterase (AChE)
in all regions. It decreased TGC in the FbC, striatum, BFb, hippocampus,
brain stem and cerebellum, and increased superoxide dismutase activity
in the FbC, cerebellum and BFb. GTLE pretreatment completely reversed
the damaging effects of AlCl3 on AA and superoxide dismutase activity,
markedly corrected COX and AChE activities, and moderately improved TGC.
GTLE alone increased COX and AChE activities in almost all regions. GTLE
reduces AlCl3 neurotoxicity probably via antioxidative effects and
improves mitochondrial and cholinergic synaptic functions through the
actions of (-)-epigallocatechin gallate and (-)-epicatechin, compounds
most abundantly found in GTLE. Our results suggest that green tea might
be beneficial in Alzheimer's disease. Copyright (c) 2013 John Wiley \&
Sons, Ltd.
Кључне речи:
green tea; aluminium; oxidative stress; Acetylcholinesterase; Active avoidance; Alzheimer's diseaseИзвор:
Phytotherapy Research, 2014, 28, 1, 82-87
DOI: 10.1002/ptr.4962
ISSN: 1099-1573