Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes
2014
Authors:
Mojić, MarijaSavic, Aleksandar
Arion, Vladimir B.
Bulatović, Mirna Z.
Poljarevic, Jelena M.
Miljković, Đorđe
Sabo, Tibor J.
Mijatović, Sanja
Maksimović-Ivanić, Danijela
Grguric-Sipka, Sanja
Document Type:
Article (Published version)
,
© 2013 Elsevier B.V.
Metadata
Show full item recordAbstract:
Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and
isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl)
propanoic acid as ligands were prepared from p-cymene ruthenium
dichloride dimer and corresponding ester. All compounds have been
characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR
spectroscopy. Single crystal X-ray structure diffraction analysis of C1
shows the usual piano-stool geometry of complexes, with coordination of
ester ligand via nitrogen donor atoms. Ligands exhibit moderate
anticancer activity (IC50 > 50 mu M), while the complexes were
significantly more cytotoxic towards various cancer cell lines,
including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0
mu M). We stress that cisplatin resistant HCT116 cell line was highly
sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M
versus IC50 > 120 mu M for cisplatin). In parallel, primary
fibroblasts-MRC-5 were remarkably less affected by these compounds. (C)
2013 Elsevier B. V. All rights reserved.
Keywords:
Apoptosis; Cancer; Organoruthenium; Amine ligandsSource:
Journal of Organometallic Chemistry, 2014, 749, 142-149
DOI: 10.1016/j.jorganchem.2013.08.041
ISSN: 0022-328X