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Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes
dc.creator | Mojić, Marija | |
dc.creator | Savic, Aleksandar | |
dc.creator | Arion, Vladimir B. | |
dc.creator | Bulatović, Mirna Z. | |
dc.creator | Poljarevic, Jelena M. | |
dc.creator | Miljković, Đorđe | |
dc.creator | Sabo, Tibor J. | |
dc.creator | Mijatović, Sanja | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Grguric-Sipka, Sanja | |
dc.date.accessioned | 2016-05-23T11:00:49Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0022-328X | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2310 | |
dc.description.abstract | Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid as ligands were prepared from p-cymene ruthenium dichloride dimer and corresponding ester. All compounds have been characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR spectroscopy. Single crystal X-ray structure diffraction analysis of C1 shows the usual piano-stool geometry of complexes, with coordination of ester ligand via nitrogen donor atoms. Ligands exhibit moderate anticancer activity (IC50 > 50 mu M), while the complexes were significantly more cytotoxic towards various cancer cell lines, including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0 mu M). We stress that cisplatin resistant HCT116 cell line was highly sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M versus IC50 > 120 mu M for cisplatin). In parallel, primary fibroblasts-MRC-5 were remarkably less affected by these compounds. (C) 2013 Elsevier B. V. All rights reserved. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological development of the Republic of Serbia {[}172035, 173013] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Journal of Organometallic Chemistry | |
dc.subject | Apoptosis | |
dc.subject | Cancer | |
dc.subject | Organoruthenium | |
dc.subject | Amine ligands | |
dc.title | Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Сабо, Тибор Ј.; Миљковић, Ђорђе М.; Aрион, Владимир Б.; Булатовић, Мирна З.; Мојић, Марија К.; Максимовић, Данијела Д.; Гргуриц-Сипка, Сања; Пољаревиц, Јелена М.; Мијатовић, Сања A.; Савиц, Aлександар; | |
dc.rights.holder | © 2013 Elsevier B.V. | |
dc.citation.volume | 749 | |
dc.identifier.doi | 10.1016/j.jorganchem.2013.08.041 | |
dc.identifier.scopus | 2-s2.0-84885363912 | |
dc.identifier.wos | 000327939000023 | |
dc.citation.spage | 142 | |
dc.citation.epage | 149 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |