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Effects of soy phytoestrogens on pituitary-ovarian function in middle-aged female rats
dc.creator | Jarić, Ivana | |
dc.creator | Živanović, Jasmina | |
dc.creator | Ajdžanović, Vladimir | |
dc.creator | Nikolić-Kokić, Aleksandra | |
dc.creator | Stankovic, Sanja D. | |
dc.creator | Trifunović, Svetlana | |
dc.creator | Milošević, Verica | |
dc.creator | Nestorović, Nataša | |
dc.date.accessioned | 2016-05-23T11:00:51Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1559-0100 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2319 | |
dc.description.abstract | The aim of this study was to assess the effects of genistein (G) and daidzein (D) on the histological, hormonal, and functional parameters of the pituitary-ovarian axis in middle-aged female rats, and to compare these effects with the effects of estradiol (E), commonly used in the prevention and treatment of menopausal symptoms. Middle-aged (12 month old) Wistar female rats subcutaneously received 35 mg/kg of G, or 35 mg/kg of D, or 0.625 mg/kg of E every day for 4 weeks. Each of the treated groups had a corresponding control group. An intact control group was also established. G and D did not change the intracellular protein content within gonadotropic and lactotropic cells, but vacuolization was observed in all the cell types. In contrast, E caused an inhibition of gonadotropic and stimulation of lactotropic cells. Also, ovaries of middle-aged female rats exposed to G or D have more healthy primordial and primary follicles and less atretic follicles. E treatment in the ovaries had a mostly negative effect, which is reflected by the increased number of atretic follicles in all tested classes. G and D provoked decrease in CuZnSOD and CAT activity, while E treatment increased MnSOD and decreased CuZnSOD and GSHPx activity. All the treatments increased serum estradiol and decreased testosterone levels, while D and E increased the serum progesterone level. In conclusion, soy phytoestrogens exhibited beneficial effects on pituitary-ovarian function in middle-aged female rats, as compared to estradiol. | en |
dc.description.sponsorship | Ministry of Education, Science and Technological Development of the Republic of Serbia {[}173009] | |
dc.language | English | |
dc.rights | restrictedAccess | |
dc.source | Endocrine | |
dc.subject | Genistein | |
dc.subject | Daidzein | |
dc.subject | Estradiol | |
dc.subject | Pituitary-ovarian function | |
dc.title | Effects of soy phytoestrogens on pituitary-ovarian function in middle-aged female rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Медиговиц, Ивана М.; Милосевиц, Верица Љ; Станковиц, Сања Д.; Трифуновиц, Светлана Л.; Несторовић, Наташа М.; Николић-Кокић, Aлександра; Зивановиц, Јасмина Б.; Aјджановић, Владимир; | |
dc.citation.issue | 3 | |
dc.citation.volume | 50 | |
dc.identifier.doi | 10.1007/s12020-015-0691-x | |
dc.identifier.scopus | 2-s2.0-84949097113 | |
dc.identifier.wos | 000370082400029 | |
dc.citation.spage | 764 | |
dc.citation.epage | 776 | |
dc.type.version | publishedVersion | en |
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