Redox implications in adipose tissue (dys)function-A new look at old acquaintances
2015
Authors:
Janković, AleksandraKorac, Aleksandra
Buzadžić, Biljana J.
Otašević, Vesna
Stančić, Ana
Daiber, Andreas
Korać, Bato
Document Type:
Review (Published version)
Metadata
Show full item recordAbstract:
Obesity is an energy balance disorder associated with dyslipidemia,
insulin resistance and diabetes type 2, also summarized with the term
metabolic syndrome or syndrome X. Increasing evidence points to
``adipocyte dysfunction{''}, rather than fat mass accretion per se, as
the key pathophysiological factor for metabolic complications in
obesity. The dysfunctional fat tissue in obesity characterizes a failure
to safely store metabolic substrates into existing hypertrophied
adipocytes and/or into new preadipocytes recruited for differentiation.
In this review we briefly summarize the potential of redox imbalance in
fat tissue as an instigator of adipocyte dysfunction in obesity. We
reveal the challenge of the adipose redox changes, insights in the
regulation of healthy expansion of adipose tissue and its reduction,
leading to glucose and lipids overflow. (C) 2015 Published by Elsevier
B.V.
Keywords:
Adipose tissue; Obesity; Insulin resistance; RedoxSource:
Redox Biology, 2015, 6, 19-32Funding / projects:
- White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders (RS-MESTD-Basic Research (BR or ON)-173055)
DOI: 10.1016/j.redox.2015.06.018
ISSN: 2213-2317