Redox control of protein degradation
2015
Autori:
Pajares, MartaJimenez-Moreno, Natalia
Dias, Irundika H. K.
Debelec, Bilge
Vučetić, Milica
Fladmark, Kari E.
Basaga, Huveyda
Ribaric, Sarno
Milisav, Irina
Cuadrado, Antonio
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Intracellular proteolysis is critical to maintain timely degradation of
altered proteins including oxidized proteins. This review attempts to
summarize the most relevant findings about oxidant protein modification,
as well as the impact of reactive oxygen species on the proteolytic
systems that regulate cell response to an oxidant environment: the
ubiquitin-proteasome system (UPS), autophagy and the unfolded protein
response (UPR). In the presence of an oxidant environment, these systems
are critical to ensure proteostasis and cell survival. An example of
altered degradation of oxidized proteins in pathology is provided for
neurodegenerative diseases. Future work will determine if protein
oxidation is a valid target to combat proteinopathics., (C) 2015 The
Authors. Published by Elsevier B.V.
Ključne reči:
Protein oxidation; Proteolysis; Proteasome; Autophagy; Unfolded protein responseIzvor:
Redox Biology, 2015, 6, 409-420Finansiranje / projekti:
- COST Action BM1203/EU-ROS
- Kidney Research UK (PDF3/2014)
DOI: 10.1016/j.redox.2015.07.003
ISSN: 2213-2317