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Redox control of protein degradation
dc.creator | Pajares, Marta | |
dc.creator | Jimenez-Moreno, Natalia | |
dc.creator | Dias, Irundika H. K. | |
dc.creator | Debelec, Bilge | |
dc.creator | Vučetić, Milica | |
dc.creator | Fladmark, Kari E. | |
dc.creator | Basaga, Huveyda | |
dc.creator | Ribaric, Sarno | |
dc.creator | Milisav, Irina | |
dc.creator | Cuadrado, Antonio | |
dc.date.accessioned | 2016-05-23T11:00:52Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 2213-2317 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2327 | |
dc.description.abstract | Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy and the unfolded protein response (UPR). In the presence of an oxidant environment, these systems are critical to ensure proteostasis and cell survival. An example of altered degradation of oxidized proteins in pathology is provided for neurodegenerative diseases. Future work will determine if protein oxidation is a valid target to combat proteinopathics., (C) 2015 The Authors. Published by Elsevier B.V. | en |
dc.description.sponsorship | European Cooperation in Science and Technology (COST Action) {[}BM1203/EU-ROS]; Kidney Research UK {[}PDF3/2014] | |
dc.language | English | |
dc.relation | COST Action BM1203/EU-ROS | |
dc.relation | Kidney Research UK (PDF3/2014) | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Redox Biology | |
dc.subject | Protein oxidation | |
dc.subject | Proteolysis | |
dc.subject | Proteasome | |
dc.subject | Autophagy | |
dc.subject | Unfolded protein response | |
dc.title | Redox control of protein degradation | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Басага, Хувеyда; Цуадрадо, Aнтонио; Пајарес, Марта; Јименез-Морено, Наталиа; Диас, Ирундика Х. К.; Милисав, Ирина; Дебелец, Билге; Вуцетиц, Милица; Рибариц, Сарно; Фладмарк, Кари Е.; | |
dc.rights.holder | © 2015 The Authors. Published by Elsevier B.V. | |
dc.citation.volume | 6 | |
dc.identifier.doi | 10.1016/j.redox.2015.07.003 | |
dc.identifier.scopus | 2-s2.0-84941793416 | |
dc.identifier.wos | 000367338700040 | |
dc.citation.spage | 409 | |
dc.citation.epage | 420 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/6081/1-s2.0-S2213231715000750-main.pdf | |
dc.citation.rank | M21 |