The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin
2015
Autori:
Katanić, JelenaMihailović, Vladimir
Matić, Sanja
Stanković, Vesna
Stanković, Nevena
Boroja, Tatjana
Mladenović, Milan
Stanić, Snezana
Kreft, Samo
Mihailović, Mirjana
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2015 Elsevier Ltd.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The effects of the methanolic extracts of Filipendula hexapetala Gilib.
aerial parts (FHA) and roots (FHR) against cisplatin induced kidney and
liver injuries in rats were investigated as well as determination of
genotoxicity and antigenotoxicity of the extracts. Treatment with FHA
and FHR significantly decreased levels of urea, uric acid, serum
transaminases, alkaline phosphatase and gamma-glutamyl transferase, and
increased the content of total protein. In addition, treatment with the
extracts significantly attenuated the cisplatin-induced oxidative stress
in kidney and liver tissues by increasing catalase and superoxide
dismutase activities and the content of reduced glutathione and
decreasing the content of thiobarbituric acid reactive substances
(TSARS). The histopathological studies confirmed the protective effects
of the extracts against cisplatin-induced kidney and liver injuries. The
extracts ameliorated cisplatin-induced genotoxicity. These results
suggest that F. hexapetala extracts are effective nephro- and
hepatoprotective agents, with potential to reduce oxidative stress and
ameliorate cisplatin-induced nephro- and hepatotoxicity.
Napomena:
Corrigendum in: Journal of Functional Foods. Volume 18, Part A, October 2015, Pages 198–212, https://doi.org/10.1016/j.jff.2016.11.017
Ključne reči:
Filipendula hexapetala; HPLC analysis; Cisplatin; Nephrotoxicity; Hepatotoxicity; Antigenotoxic effectIzvor:
Journal of Functional Foods, 2015, 18, Part A, 198-212Finansiranje / projekti:
- Simultana bioremedijacija i soilifikacija degradiranih prostora, za očuvanje prirodnih resursa biološki aktivnih supstanci i razvoj i proizvodnju biomaterijala i dijetetskih proizvoda (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-43004)
- Preklinička ispitivanja bioaktivnih supstanci (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41010)
DOI: 10.1016/j.jff.2015.07.004
ISSN: 1756-4646
WoS: 000367757400020
Scopus: 2-s2.0-84940571082
URI
https://radar.ibiss.bg.ac.rs/handle/123456789/2352http://www.sciencedirect.com/science/article/pii/S175646461500362X