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The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin
dc.creator | Katanić, Jelena | |
dc.creator | Mihailović, Vladimir | |
dc.creator | Matić, Sanja | |
dc.creator | Stanković, Vesna | |
dc.creator | Stanković, Nevena | |
dc.creator | Boroja, Tatjana | |
dc.creator | Mladenović, Milan | |
dc.creator | Stanić, Snezana | |
dc.creator | Kreft, Samo | |
dc.creator | Mihailović, Mirjana | |
dc.date.accessioned | 2017-11-23T11:27:00Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2352 | |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S175646461500362X | |
dc.description.abstract | The effects of the methanolic extracts of Filipendula hexapetala Gilib. aerial parts (FHA) and roots (FHR) against cisplatin induced kidney and liver injuries in rats were investigated as well as determination of genotoxicity and antigenotoxicity of the extracts. Treatment with FHA and FHR significantly decreased levels of urea, uric acid, serum transaminases, alkaline phosphatase and gamma-glutamyl transferase, and increased the content of total protein. In addition, treatment with the extracts significantly attenuated the cisplatin-induced oxidative stress in kidney and liver tissues by increasing catalase and superoxide dismutase activities and the content of reduced glutathione and decreasing the content of thiobarbituric acid reactive substances (TSARS). The histopathological studies confirmed the protective effects of the extracts against cisplatin-induced kidney and liver injuries. The extracts ameliorated cisplatin-induced genotoxicity. These results suggest that F. hexapetala extracts are effective nephro- and hepatoprotective agents, with potential to reduce oxidative stress and ameliorate cisplatin-induced nephro- and hepatotoxicity. | en |
dc.language | English | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41010/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Functional Foods | |
dc.subject | Filipendula hexapetala | |
dc.subject | HPLC analysis | |
dc.subject | Cisplatin | |
dc.subject | Nephrotoxicity | |
dc.subject | Hepatotoxicity | |
dc.subject | Antigenotoxic effect | |
dc.title | The ameliorating effect of Filipendula hexapetala extracts on hepatorenal toxicity of cisplatin | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Станковић, Весна; Бороја, Татјана; Младеновић, Милан; Станић, Снезана; Крефт, Само; Михаиловић, Мирјана; Катанић, Јелена; Михаиловић, Владимир; Матић, Сања; Станковић, Невена; | |
dc.rights.holder | © 2015 Elsevier Ltd. | |
dc.citation.issue | Part A | |
dc.citation.volume | 18 | |
dc.description.note | Corrigendum in: Journal of Functional Foods. Volume 18, Part A, October 2015, Pages 198–212, [https://doi.org/10.1016/j.jff.2016.11.017] | en |
dc.identifier.doi | 10.1016/j.jff.2015.07.004 | |
dc.identifier.scopus | 2-s2.0-84940571082 | |
dc.identifier.wos | 000367757400020 | |
dc.citation.spage | 198 | |
dc.citation.epage | 212 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | aM21 |