Metaboličke karakteristike sindroma policističnih jajnika u visceralnom masnom tkivu i leptinska rezistencija u hipotalamusu pacova tretiranog 5alfa-dihidrotestosteronom: uloga glukokortikosteroida
Metabolic characteristics of polycistic ovary syndrom in the visceral adipose tissue and leptin resistance in the hypothalamus of the rat treated with 5alfa-dihydrotestosterone: role of glycocorticoids
2016
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Authors:
Radovanović, MarinaContributors
Vojnović-Milutinović, DanijelaMatić, Gordana
Macut, Đuro
Vojnović-Milutinović, Danijela
Matić, Gordana
Document Type:
Doctoral thesis (Published version)
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Show full item recordAbstract:
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of women of reproductive age. It is a heterogenous disorder, with hyperandrogenism, chronic anovulation and polycystic ovaries as basic characterisctics, and features of the metabolic syndrome, such as insulin resistance, obesity, dislipidemia and hypertension as associated metabolic characteristics.Pathophysiology and aetiology of PCOS and interlinks between its symptoms are yet to be clarified. It is generally considered that the reproductive, endocrine and metabolic features of PCOS create a vicious circle in the centre of which lies hyperandrogenemia, stimulated by visceral obesity, disturbed lipid metabolism, inflammation and insulin resistance.By functioning antagonistically with insulin, glucocorticoids influence the genesis of visceral obesity and contribute to the pathophysiology of the metabolic syndrome. Their tissue-specific effects stimulate systemic insulin resistance. In addition, glucocorticoids generally exhibit antiinflamatory actions. In obesity, however, they show an ability to stimulate proinflammatory factors.Leptin is a hormone with anorexigenic effects in the hypothalamus. In the course of energy intake and consumption control it works synergistically with insulin, but antagonizes the actions of glucocorticoids. Increased secretion of leptin - hyperleptinemia and leptin resistance are common consequences of obesity...
Keywords:
PCOS; Glucocorticoids; DHT; Visceral adipose tissue; Hypothalamus; Leptin; Insulin; InflammationSource:
University of Belgrade, Faculty of Biology, 2016, 1-139Funding / projects:
- Eksperimenti predstavljeni u ovoj doktorskoj disertaciji urađeni su u Odeljenju za biohemiju Instituta za biološka istraživanja „Siniša Stanković“ Univerziteta u Beogradu, u okviru projekta br. 41009 „Uloga steroidnih hormona u neuroendokrinoj adaptaciji na stres i patofiziologiji metaboličkog sindroma – molekularni mehanizmi i kliničke implikacije“, finansiranog od strane Ministarstva prosvete, nauke i tehnološkog razvoja Republike Srbije i ostvarenog pod rukovodstvom prof. dr Gordane Matić.
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http://eteze.bg.ac.rs/application/showtheses?thesesId=3045https://fedorabg.bg.ac.rs/fedora/get/o:11286/bdef:Content/download
http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=1025053106
http://nardus.mpn.gov.rs/123456789/5666
https://radar.ibiss.bg.ac.rs/handle/123456789/2370