Interventions for age-related diseases: Shifting the paradigm
2016
Преузимање 🢃
Аутори:
Figueira, InêsFernandes, Adelaide
Mladenović, Aleksandra
Lopez-Contreras, Andres
Henriques, Catarina M.
Selman, Colin
Ferreiro, Elisabete
Gonos, Efstathios S.
Trejo, José Luis
Misra, Juhi
Rasmussen, Lene Juel
Xapelli, Sara
Ellam, Timothy
Bellantuono, Ilaria
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.
Кључне речи:
Multimorbidity; Ageing; Chronic diseases; Geroprotectors; GeroscienceИзвор:
Mechanisms of Ageing and Development, 2016, 160, 69-92Финансирање / пројекти:
- Пластичност мозга током старења: утицај дијеталне рестрикције и анестезије (RS-MESTD-Basic Research (BR or ON)-173056)
- COST Action (BM1402: MouseAGE)
- Danish National Research Foundation (DNRF115)
- Danish Council for Independent Research (Sapere Aude, DFF-Starting Grant 2014)
- Danish Cancer Society (KBVU-2014)
- Fundação para a Ciência e Tecnologia (FCT, Portugal), SFRH/BPD/76642/2011 and SFRH/BD/86584/2012
DOI: 10.1016/j.mad.2016.09.009
ISSN: 0047-6374
PubMed: 27693441
WoS: 000390622400008
Scopus: 2-s2.0-84999035290
URI
http://linkinghub.elsevier.com/retrieve/pii/S0047637416301816https://www.scopus.com/record/display.uri?eid=2-s2.0-84999035290&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=BC81928C1802E221B1A9A8D8F9963BDB.wsnAw8kcdt7IPYLO0V48gA%3A1#
https://radar.ibiss.bg.ac.rs/handle/123456789/2479