Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment
2016
Autori:
Spasojević, DragicaZmejkoski, Danica
Glamočlija, Jasmina
Nikolić, Miloš
Soković, Marina
Milošević, Verica
Jarić, Ivana
Stojanović, Marijana
Marinković, Emilija
Barisani-Asenbauer, Talin
Prodanović, Radivoje
Jovanović, Miloš
Radotić, Ksenija
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2016 Elsevier B.V. and International Society of Chemotherapy
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP−Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.
Ključne reči:
Lignin model polymer; Alginate; Antimicrobial activity; Bacterial biofilm; Wound treatmentIzvor:
International Journal of Antimicrobial Agents, 2016, 48, 6, 732-735Finansiranje / projekti:
- Alergeni, antitela, enzimi i mali fiziološki značajni molekuli: dizajn, struktura, funkcija i značaj (RS-MESTD-Basic Research (BR or ON)-172049)
- Ispitivanja odnosa struktura-funkcija u ćelijskom zidu biljaka i izmene strukture zida enzimskim inženjeringom (RS-MESTD-Basic Research (BR or ON)-173017)
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-MESTD-Basic Research (BR or ON)-173032)
- info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/III45012/RS// (RS-MESTD-Basic Research (BR or ON)-III45012)
DOI: 10.1016/j.ijantimicag.2016.08.014
ISSN: 0924-8579
PubMed: 27742207
WoS: 000389520700024
Scopus: 2-s2.0-85000995852
URI
http://linkinghub.elsevier.com/retrieve/pii/S0924857916302679https://www.scopus.com/record/display.uri?eid=2-s2.0-85000995852&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=5EA0B882AD39CF37A9F768C8B10917B5.wsnAw8kcdt7IPYLO0V48gA%3A1#
https://radar.ibiss.bg.ac.rs/handle/123456789/2480