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Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment

dc.creatorSpasojević, Dragica
dc.creatorZmejkoski, Danica
dc.creatorGlamočlija, Jasmina
dc.creatorNikolić, Miloš
dc.creatorSoković, Marina
dc.creatorMilošević, Verica
dc.creatorJarić, Ivana
dc.creatorStojanović, Marijana
dc.creatorMarinković, Emilija
dc.creatorBarisani-Asenbauer, Talin
dc.creatorProdanović, Radivoje
dc.creatorJovanović, Miloš
dc.creatorRadotić, Ksenija
dc.date.accessioned2017-11-23T11:32:51Z
dc.date.available2016-12-20T16:19:41Z
dc.date.issued2016
dc.identifier.issn0924-8579
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0924857916302679
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85000995852&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=5EA0B882AD39CF37A9F768C8B10917B5.wsnAw8kcdt7IPYLO0V48gA%3A1#
dc.identifier.urihttps://radar.ibiss.bg.ac.rs/handle/123456789/2480
dc.description.abstractNowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP−Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/III45012/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Antimicrobial Agents
dc.subjectLignin model polymer
dc.subjectAlginate
dc.subjectAntimicrobial activity
dc.subjectBacterial biofilm
dc.subjectWound treatment
dc.titleLignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatmenten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГламочлија, Јасмина; Јарић, Ивана; Продановић, Радивоје; Соковић, Марина; Спасојевић, Драгица; Змејкоски, Даница; Барисани-Aсенбауер, Талин; Радотић, Ксенија; Јовановић, Милош; Николић, Милош; Милошевић, Верица; Стојановић, Маријана; Маринковић, Емилија;
dc.rights.holder© 2016 Elsevier B.V. and International Society of Chemotherapy
dc.citation.issue6
dc.citation.volume48
dc.identifier.doi10.1016/j.ijantimicag.2016.08.014
dc.identifier.pmid27742207
dc.identifier.scopus2-s2.0-85000995852
dc.identifier.wos000389520700024
dc.citation.apaSpasojević, D., Zmejkoski, D., Glamočlija, J., Nikolić, M., Soković, M., Milošević, V., Jarić, I., et al. (2016). Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. International Journal of Antimicrobial Agents, 48(6), 732-735.
dc.citation.vancouverSpasojević D, Zmejkoski D, Glamočlija J, Nikolić M, Soković M, Milošević V, Jarić I, Stojanović M, Marinković E, Barisani-Asenbauer T, Prodanović R, Jovanović M, Radotić K. Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. Int J Antimicrob Agents. 2016;48(6):732-5.
dc.citation.spage732
dc.citation.epage735
dc.type.versionpublishedVersionen
dc.citation.rankM21


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