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Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line
dc.creator | Bensing, Christian | |
dc.creator | Mojić, Marija | |
dc.creator | Gómez-Ruiz, Santiago | |
dc.creator | Carralero, Sandra | |
dc.creator | Dojčinović, Biljana | |
dc.creator | Maksimović-Ivanić, Danijela | |
dc.creator | Mijatović, Sanja | |
dc.creator | Kaluđerović, Goran N. | |
dc.date.accessioned | 2016-12-21T15:15:41Z | |
dc.date.available | 2016-12-21T15:15:41Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1477-9226 | |
dc.identifier.uri | http://xlink.rsc.org/?DOI=C6DT03519A | |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85000774313&origin=SingleRecordEmailAlert&dgcid=scalert_sc_search_email&txGid=691E27A4B52E4CB98111082A19AFDEEC.wsnAw8kcdt7IPYLO0V48gA%3A11# | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2481 | |
dc.description.abstract | SBA-15|Sn3, a mesoporous silica-based material (derivative of SBA-15) loaded with an organotin compound Ph3Sn(CH2)3OH (Sn3), possesses improved antitumor potential against the A2780 high-grade serous ovarian carcinoma cell line in comparison to Sn3. It is demonstrated that both the compound and the nanostructured material are internalized by the A2780 cells. A similar mode of action of Sn3 and SBA-15|Sn3 against the A2780 cell line was found. Explicitly, induction of apoptosis, caspase 2, 3, 8 and 9 activation, accumulation of cells in the hypodiploid phase as well as accumulation of ROS were observed. Interestingly, Sn3 loaded in the mesoporous silica-based material needed to reach a concentration 3.5 times lower than the IC50 value of the Sn3 compound, pointing out a higher effect of the SBA-15|Sn3 than Sn3 alone. Clonogenic potential, growth in 3D culture as well as mobility of cells were disturbed in the presence of SBA-15|Sn3. Such behavior could be associated with the suppression of p-38 MAPK. Less profound effect of Sn3 compared to SBA-15|Sn3 could be attributed to a different regulation of p-38 and STAT-3, which are mainly responsible for an appropriate cellular response to diverse stimuli or metastatic properties. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.relation | Ministerio de Economía y Competitividad, Spain (Grant No. CTQ2015-66164-R | |
dc.relation | Universidad Rey Juan Carlos-Banco de Santander (Excellence Group QUINANOAP) | |
dc.rights | restrictedAccess | |
dc.source | Dalton Transactions | |
dc.subject | Cell culture | |
dc.subject | Cell death | |
dc.subject | Cells | |
dc.subject | Cytology | |
dc.subject | Organometallics | |
dc.subject | Silica | |
dc.subject | Tin | |
dc.subject | Carrier systems | |
dc.subject | Cellular response | |
dc.subject | Clonogenic potential | |
dc.subject | Functionalized | |
dc.subject | Mesoporous Silica | |
dc.subject | Mesoporous silica-based materials | |
dc.subject | Organotin compound | |
dc.subject | Ovarian carcinoma cell | |
dc.title | Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Калуђеровић, Горан Н.; Дојчиновић, Биљана; Мојић, Марија; Царралеро, Сандра; Бенсинг, Цхристиан; Мијатовић, Сања; Гóмез-Руиз, Сантиаго; Максимовић-Иванић, Данијела; | |
dc.rights.holder | © 2016 The Royal Society of Chemistry | |
dc.citation.issue | 47 | |
dc.citation.volume | 45 | |
dc.identifier.doi | 10.1039/C6DT03519A | |
dc.identifier.pmid | 27847952 | |
dc.identifier.scopus | 2-s2.0-85000774313 | |
dc.identifier.wos | 000390082900025 | |
dc.citation.apa | Bensing, C., Mojić, M., Gómez-Ruiz, S., Carralero, S., Dojčinović, B., Maksimović-Ivanić, D., Mijatović, S., et al. (2016). Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2) 3 OH against the A2780 ovarian carcinoma cell line. Dalton Transactions, 45(47), 18984-18993. | |
dc.citation.vancouver | Bensing C, Mojić M, Gómez-Ruiz S, Carralero S, Dojčinović B, Maksimović-Ivanić D, Mijatović S, Kaluđerović GN. Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph 3 Sn(CH 2 ) 3 OH against the A2780 ovarian carcinoma cell line. Dalt Trans. 2016;45(47):18984-93. | |
dc.citation.spage | 18984 | |
dc.citation.epage | 18993 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |