Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses
2016
Аутори:
Demenesku, JelenaPopov Aleksandrov, Aleksandra
Mirkov, Ivana
Ninkov, Marina
Zolotarevski, Lidija
Kataranovski, Dragan
Brceski, Ilija
Kataranovski, Milena
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2016 Elsevier Ireland Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-γ)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b+ cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-γ responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity.
Извор:
Toxicology Letters, 2016, 256, 33-43Финансирање / пројекти:
- Имуномодулаторни ефекти ксенобиотика и биотичких фактора животне средине на популације мишоликих глодара (RS-MESTD-Basic Research (BR or ON)-173039)
DOI: 10.1016/j.toxlet.2016.05.022
ISSN: 0378-4274
PubMed: 27234498
WoS: 000378049900004
Scopus: 2-s2.0-84971473046
URI
http://linkinghub.elsevier.com/retrieve/pii/S037842741630128Xhttps://radar.ibiss.bg.ac.rs/handle/123456789/2532