Chemical composition of the mushroom Meripilus giganteus Karst. and bioactive properties of its methanolic extract
2017
Аутори:
Stojković, DejanKovačević-Grujičić, Nataša
Reis, Filipa S.
Davidović, Slobodan
Barros, Lillian
Popović, Jelena
Petrović, Isidora
Pavić, Aleksandar
Glamočlija, Jasmina
Ćirić, Ana
Stevanović, Milena
Ferreira, Isabel C.F.R.
Soković, Marina
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2017 Elsevier Ltd
Метаподаци
Приказ свих података о документуАпстракт:
Wild Meripilus giganteus Karst belongs to the order Polyporales, in which some members are known to possess a wide range of pharmacological properties. M. giganteus showed to be rich in carbohydrates (74.49 g/100 g) and proteins (15.94 g/100 g), presenting low fat content (1.51 g/100 g). Chemical composition was determined by using chromatographic techniques. Also, various bioactive compounds were detected including all four tocopherol isoforms with δ- and γ-tocopherols being predominant (123.35 and 77.80 μg/100 g, respectively); five organic acids (oxalic, malic, quinic, citric and fumaric acids) with predominant malic acid (3.17 g/100 g); and three phenolic acids and related compounds (p-hydroxybenzoic, p-coumaric and cinnamic acids; 1010, 2420 and 340 μg/100 g, respectively). M. giganteus methanolic extract exhibited antioxidant activity tested by five different assays with the strongest potential in TBARS assay (EC50 0.31 mg/mL); and antimicrobial activities (MIC/MBC 0.0125–5 mg/mL; MIC/MFC 0.025–0.4 mg/mL). Furthermore, treatment of cervical carcinoma cell line (HeLa) led to reduction in cell's viability in MTT assay (IC50 0.41 mg/mL after 48 h), induced process of apoptosis and inhibited cell's migration in vitro. The analysed extract was not toxic for zebrafish embryos (at 0.5 mg/mL), indicating its biosafety and potential application as a dietary supplement in chemoprevention.
Кључне речи:
Meripilus giganteus Karst.; Antioxidant activity; Antimicrobial activity; Antitumor activity; ApoptosisУ:
- LWT - Food Science and Technology (2017), 79: 454-462
DOI: 10.1016/j.lwt.2017.01.045
ISSN: 0023-6438
WoS: 000395603100056
Scopus: 2-s2.0-85012273334
URI
http://linkinghub.elsevier.com/retrieve/pii/S0023643817300452https://radar.ibiss.bg.ac.rs/handle/123456789/2580