An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.
2017
Аутори:
Pejin, BorisĆirić, Ana
Dimitrić Marković, Jasmina
Glamočlija, Jasmina
Nikolić, Miloš
Soković, Marina
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2016 Informa UK Limited, trading as Taylor & Francis Group
Метаподаци
Приказ свих података о документуАпстракт:
Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25 μg/mL) being the most active (43%). In comparison, ampicillin (c 93.75 μg/mL) and streptomycin (c 21.25 μg/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225 μg/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.
Кључне речи:
Flavanone-7-O-glucoside; Anti-biofilm activity; Bacterial resistance; Delphinidin; Infectious diseases; Low sub-MICИзвор:
Natural product research, 2017, 31, 10, 1177-1180Финансирање / пројекти:
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)
DOI: 10.1080/14786419.2016.1222386
ISSN: 1478-6419
PubMed: 27539815
WoS: 000395151500011
Scopus: 2-s2.0-84982276502
URI
https://www.tandfonline.com/doi/full/10.1080/14786419.2016.1222386http://www.ncbi.nlm.nih.gov/pubmed/27539815
https://radar.ibiss.bg.ac.rs/handle/123456789/2623