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An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1.
dc.creator | Pejin, Boris | |
dc.creator | Ćirić, Ana | |
dc.creator | Dimitrić Marković, Jasmina | |
dc.creator | Glamočlija, Jasmina | |
dc.creator | Nikolić, Miloš | |
dc.creator | Soković, Marina | |
dc.date.accessioned | 2017-11-23T11:32:46Z | |
dc.date.available | 2017-11-23T11:32:46Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/14786419.2016.1222386 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/27539815 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2623 | |
dc.description.abstract | Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25 μg/mL) being the most active (43%). In comparison, ampicillin (c 93.75 μg/mL) and streptomycin (c 21.25 μg/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225 μg/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural product research | |
dc.subject | Flavanone-7-O-glucoside | |
dc.subject | Anti-biofilm activity | |
dc.subject | Bacterial resistance | |
dc.subject | Delphinidin | |
dc.subject | Infectious diseases | |
dc.subject | Low sub-MIC | |
dc.title | An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Димитрић Марковић, Јасмина; Гламочлија, Јасмина; Соковић, Марина; Николић, Милош; Ћирић, Aна; Пејин, Борис; | |
dc.rights.holder | © 2016 Informa UK Limited, trading as Taylor & Francis Group | |
dc.citation.issue | 10 | |
dc.citation.volume | 31 | |
dc.identifier.doi | 10.1080/14786419.2016.1222386 | |
dc.identifier.pmid | 27539815 | |
dc.identifier.scopus | 2-s2.0-84982276502 | |
dc.identifier.wos | 000395151500011 | |
dc.citation.apa | Pejin, B., Ciric, A., Dimitric Markovic, J., Glamoclija, J., Nikolic, M. & Sokovic, M. (2017). An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. Natural product research, 31(10), 1177-1180. | |
dc.citation.vancouver | Pejin B, Ciric A, Dimitric Markovic J, Glamoclija J, Nikolic M, Sokovic M. An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. Nat Prod Res. 2017;31(10):1177-80. | |
dc.citation.spage | 1177 | |
dc.citation.epage | 1180 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 |
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