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Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles
dc.creator | Lopes-Rodrigues, Vanessa | |
dc.creator | Di Luca, Alessio | |
dc.creator | Mleczko, Justyna | |
dc.creator | Meleady, Paula | |
dc.creator | Henry, Michael | |
dc.creator | Pešić, Milica | |
dc.creator | Cabrera, Diana | |
dc.creator | van Liempd, Sebastiaan | |
dc.creator | Lima, Raquel T. | |
dc.creator | O’Connor, Robert | |
dc.creator | Falcon-Perez, Juan M. | |
dc.creator | Vasconcelos, M. Helena | |
dc.date.accessioned | 2017-11-23T11:29:47Z | |
dc.date.available | 2017-11-23T11:29:47Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://www.nature.com/articles/srep44541 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2683 | |
dc.description.abstract | Multidrug resistance (MDR) is a serious obstacle to efficient cancer treatment. Overexpression of P-glycoprotein (P-gp) plays a significant role in MDR. Recent studies proved that targeting cellular metabolism could sensitize MDR cells. In addition, metabolic alterations could affect the extracellular vesicles (EVs) cargo and release. This study aimed to: i) identify metabolic alterations in P-gp overexpressing cells that could be involved in the development of MDR and, ii) identify a potential role for the EVs in the acquisition of the MDR. Two different pairs of MDR and their drug-sensitive counterpart cancer cell lines were used. Our results showed that MDR (P-gp overexpressing) cells have a different metabolic profile from their drug-sensitive counterparts, demonstrating decreases in the pentose phosphate pathway and oxidative phosphorylation rate; increases in glutathione metabolism and glycolysis; and alterations in the methionine/S-adenosylmethionine pathway. Remarkably, EVs from MDR cells were capable of stimulating a metabolic switch in the drug-sensitive cancer cells, towards a MDR phenotype. In conclusion, obtained results contribute to the growing knowledge about metabolic alterations in MDR cells and the role of EVs in the intercellular transfer of MDR. The specific metabolic alterations identified in this study may be further developed as targets for overcoming MDR. | en |
dc.relation | NORTE-01-0145-FEDER-000029 | |
dc.relation | POCI-01-0145-FEDER-007274 | |
dc.relation | ERDF (FEDER) | |
dc.relation | SFRH/BD/87646/2012 | |
dc.relation | FRH/BPD/68787/2010 | |
dc.relation | ME-HaD, BM1202 | |
dc.relation | ECOST-STSM-BM1202-180216-071544 | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.title | Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Цабрера, Диана; Мелеадy, Паула; Лопес-Родригуес, Ванесса; Ди Луца, Aлессио; Млецзко, Јустyна; О’Цоннор, Роберт; Лима, Раqуел Т.; ван Лиемпд, Себастиаан; Песиц, Милица; Хенрy, Мицхаел; Васцонцелос, М. Хелена; Фалцон-Перез, Јуан М.; | |
dc.rights.holder | © The Author(s) 2017. | |
dc.citation.volume | 7 | |
dc.description.other | Scientific Reports (2017), 7: 44541 | |
dc.identifier.doi | 10.1038/srep44541 | |
dc.identifier.pmid | 28303926 | |
dc.identifier.scopus | 2-s2.0-85015308172 | |
dc.identifier.wos | 000397000300001 | |
dc.citation.apa | Lopes-Rodrigues, V., Di Luca, A., Mleczko, J., Meleady, P., Henry, M., Pesic, M., Cabrera, D., et al. (2017). Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles. Scientific Reports, 7, 44541. | |
dc.citation.vancouver | Lopes-Rodrigues V, Di Luca A, Mleczko J, Meleady P, Henry M, Pesic M, Cabrera D, van Liempd S, Lima RT, O’Connor R, Falcon-Perez JM, Vasconcelos MH. Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles. Sci Rep. 2017;7:44541. | |
dc.citation.spage | 44541 | |
dc.citation.epage | 44541 | |
dc.type.version | publishedVersion | en |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/3390/SciRep_2017_7_44541.pdf | |
dc.citation.rank | M21 |