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Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats
dc.creator | Miler, Marko | |
dc.creator | Živanović, Jasmina | |
dc.creator | Ajdžanović, Vladimir | |
dc.creator | Oreščanin Dušić, Zorana | |
dc.creator | Milenković, Dragan | |
dc.creator | Konić-Ristić, Aleksandra | |
dc.creator | Blagojević, Duško | |
dc.creator | Milošević, Verica | |
dc.creator | Šošić-Jurjević, Branka | |
dc.date.accessioned | 2017-03-29T12:35:36Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0531-5565 | |
dc.identifier.uri | http://linkinghub.elsevier.com/retrieve/pii/S053155651630290X | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2689 | |
dc.description.abstract | This study aimed to investigate effects of citrus flavanones naringenin (NAR) and hesperetin (HES) on liver antioxidant status and membrane phospholipid composition in 24-month-old rats. NAR and HES (15 mg/kg) were administrated orally to male Wistar rats, once per day, for 4 weeks. Control group received either vehicle (sunflower oil) or remained intact. The results showed decreased (p < 0.05) activity of antioxidant enzymes (AOE), specifically catalase (CAT), superoxide dismutase (SOD) 1 and glutathione reductase (GR) in the liver of intact control old-aged rats in comparison to young intact controls. Flavanone administration to old-aged males increased (p < 0.05) examined AOE activities in comparison to vehicle-administered animals. Namely, NAR was more potent in comparison to HES regarding the increase (p < 0.05) in activities of examined antioxidant enzymes (SOD 1 and 2, glutathione peroxidase-GPx and GR) and the liver glutathione (GSH), while HES elevated (p < 0.05) only activity of CAT and GR. Both flavanones significantly decreased (p < 0.05) TBARS and improved (p < 0.05) membrane phospholipid composition in favor of n-3 PUFA and n-6/n-3 PUFA ratio. Both flavanones did not affect liver histology and reduced (p < 0.05) alanine aminotransferase and aspartate aminotransferase levels in serum. The results of this study indicate beneficial potential of citrus flavanones in the old-aged rat liver. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173009/RS// | |
dc.rights | restrictedAccess | |
dc.source | Experimental Gerontology | |
dc.subject | Antioxidant system | |
dc.subject | Citrus flavanones | |
dc.subject | Liver | |
dc.subject | Old age rats | |
dc.subject | Phospholipid composition | |
dc.title | Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Миленковић, Драган; Благојевић, Душко; Милер, Марко; Aјджановић, Владимир; Шошић-Јурјевић, Бранка; Милошевић, Верица; Живановић, Јасмина; Орешчанин Душић, Зорана; Конић-Ристић, Aлександра; | |
dc.rights.holder | © 2016 Elsevier Inc. | |
dc.citation.volume | 84 | |
dc.identifier.doi | 10.1016/j.exger.2016.08.014 | |
dc.identifier.pmid | 27587005 | |
dc.identifier.scopus | 2-s2.0-84984829170 | |
dc.identifier.wos | 000385490900006 | |
dc.citation.apa | Miler, M., Živanović, J., Ajdžanović, V., Oreščanin-Dušić, Z., Milenković, D., Konić-Ristić, A., Blagojević, D., et al. (2016). Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Experimental Gerontology, 84, 49–60. | |
dc.citation.vancouver | Miler M, Živanović J, Ajdžanović V, Oreščanin-Dušić Z, Milenković D, Konić-Ristić A, Blagojević D, Milošević V, Šošić-Jurjević B. Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Exp Gerontol. 2016;84:49–60. | |
dc.citation.spage | 49 | |
dc.citation.epage | 60 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M21 |