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Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines
| dc.creator | Ljujić, Mila | |
| dc.creator | Mijatović, Sanja | |
| dc.creator | Bulatović, Mirna | |
| dc.creator | Mojić, Marija | |
| dc.creator | Maksimović-Ivanić, Danijela | |
| dc.creator | Radojković, Dragica | |
| dc.creator | Topić, Aleksandra | |
| dc.date.accessioned | 2017-11-23T11:33:30Z | |
| dc.date.available | 2900-01-01 | |
| dc.date.issued | 2017 | |
| dc.identifier.issn | 1219-4956 | |
| dc.identifier.uri | http://link.springer.com/10.1007/s12253-016-0104-3 | |
| dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2729 | |
| dc.description.abstract | Increased circulating alpha-1-antitrypsin (AAT) correlates with cancer stage/aggressiveness, but its role in cancer biology is unclear. We revealed antagonistic effect of AAT to cisplatin-induced cytotoxicity in prostate (PC3) and melanoma (A375) cancer cell lines. Moreover, AAT abrogated cytotoxicity of MEK inhibitor U0126 in PC3 cell line. Weaker antagonistic effect of AAT on cytotoxicity of PI3/Akt and NF-kB inhibitors was also observed. In addition, cisplatin increased AAT gene expression in transfected PC3 cells. However, AAT derived from transfected PC3 cells did not antagonize cisplatin-induced cytotoxicity. In conclusion, these results suggest possible association between high circulating AAT and cisplatin resistance. | en |
| dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
| dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS// | |
| dc.rights | restrictedAccess | |
| dc.source | Pathology & Oncology Research | |
| dc.subject | Alpha-1-antitrypsin | |
| dc.subject | Cisplatin | |
| dc.subject | Melanoma cancer | |
| dc.subject | Prostate cancer | |
| dc.title | Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines | en |
| dc.type | article | |
| dc.rights.license | ARR | |
| dcterms.abstract | Максимовић-Иванић, Данијела; Мојић, Марија; Мијатовић, Сања; Булатовић, Мирна; Љујић, Мила; Радојковић, Драгица; Топић, Aлександра; | |
| dc.rights.holder | © 2016, Arányi Lajos Foundation | |
| dc.citation.issue | 2 | |
| dc.citation.volume | 23 | |
| dc.identifier.doi | 10.1007/s12253-016-0104-3 | |
| dc.identifier.pmid | 27617337 | |
| dc.identifier.scopus | 2-s2.0-85016626907 | |
| dc.identifier.wos | 000399000200014 | |
| dc.citation.apa | Ljujic, M., Mijatovic, S., Bulatovic, M. Z., Mojic, M., Maksimovic-Ivanic, D., Radojkovic, D., & Topic, A. (2017). Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines. Pathology & Oncology Research, 23(2), 335–343. | |
| dc.citation.vancouver | Ljujic M, Mijatovic S, Bulatovic MZ, Mojic M, Maksimovic-Ivanic D, Radojkovic D, Topic A. Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines. Pathol Oncol Res. 2017;23(2):335–43. | |
| dc.citation.spage | 335 | |
| dc.citation.epage | 343 | |
| dc.type.version | publishedVersion | en |
| dc.citation.rank | M22 |
