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Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity
dc.creator | Šavikin, Katarina P. | |
dc.creator | Krstić Milošević, Dijana | |
dc.creator | Menković, Nebojša R. | |
dc.creator | Beara, Ivana N. | |
dc.creator | Mrkonjić, Zorica O. | |
dc.creator | Pljevljakušić, Dejan S. | |
dc.date.accessioned | 2017-11-23T11:32:09Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1934-578X | |
dc.identifier.uri | http://www.naturalproduct.us/ | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2756 | |
dc.description.abstract | The present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. Ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC50 = 29.7 μg/g) than the berry extract, as well as in the relative reducing power on Fe3+. Anti-inflammatory potential was studied by means of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibitory activity; both extracts evinced activity. Furthermore, C. orientalis leaf extract showed a concentration dependent inhibition of COX-1 pathway products 12-HHT and TXB2, reaching IC50 values below the lowest applied concentration (68.9% and 55.2% of 12-HHT and TXB2 production inhibition, respectively, at concentration of 0.4 mg/mL). Although inhibitors such as acetylsalicylic acid and quercetin showed higher activity, this study demonstrates that the investigated extracts are potential anti-inflammatory agents. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46013/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Communications | |
dc.subject | Anti-inflammatory | |
dc.subject | Hawthorn | |
dc.subject | Hyperoside | |
dc.subject | Phenolics | |
dc.subject | Radical scavenging | |
dc.subject | Reducing power | |
dc.title | Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity | en |
dc.type | conferenceObject | |
dc.rights.license | ARR | |
dcterms.abstract | Шавикин, Катарина П.; Крстић Милошевић, Дијана; Пљевљакушић, Дејан С.; Мркоњић, Зорица О.; Беара, Ивана Н.; Менковић, Небојша Р.; | |
dc.rights.holder | © Natural Product Incorporation | |
dc.citation.issue | 2 | |
dc.citation.volume | 12 | |
dc.identifier.doi | 10.1177/1934578x1701200204 | |
dc.identifier.scopus | 2-s2.0-85019124206 | |
dc.identifier.wos | 000395229200006 | |
dc.citation.apa | Šavikin, K. P., Krstić-Milošević, D., Menković, N. R., Beara, I. N., Mrkonjić, Z. O., & Pljevljakušić, D. S. (2017). Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity. Natural Product Communications, 12(2), 159–162. | |
dc.citation.vancouver | Šavikin KP, Krstić-Milošević D, Menković NR, Beara IN, Mrkonjić ZO, Pljevljakušić DS. Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity. Nat Prod Commun. 2017;12(2):159–62. | |
dc.citation.spage | 159 | |
dc.citation.epage | 162 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | M23 |