Dry olive leaf extract (DOLE) down-regulates the progression of experimental immune-mediated diabetes by modulation of cytokine profile in the draining lymph nodes
2011
Аутори:
Saksida, TamaraMiljković, Đorđe
Dekanski, Dragana P.
Stojanović, Ivana D.
Stošić-Grujičić, Stanislava
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
We have recently demonstrated the beneficial effects of dry olive leaf extract (DOLE) in two preclinical models of type 1 diabetes. Here we analyze the potential mechanisms underlying diabetes amelioration at the level of lymph node drainage. Treatment of C57BL/6 mice with DOLE during induction of diabetes with multiple low doses of streptozotocin (MLD-SZ) modulated cytokine expression and production in pancreatic lymph node cells, thereby changing the balance between potentially pathogenic and down-regulating cytokines. These results support the immunoregulatory potential of DOLE which takes place at the level of lymph node drainage and preserves the target tissue from autoimmune attack.
Кључне речи:
Autoimmune diabetes; streptozotocin; olive leaf extract; cytokine; inflammation; C57BL/6 miceИзвор:
Archives of Biological Sciences, 2011, 63, 2, 289-297
DOI: 10.2298/ABS1102289S
ISSN: 0354-4664