Synthesis, characterization and cytotoxicity of a new palladium(II) complex with a coumarin-derived ligand 3-(1-(3-hydroxypropylamino)ethylidene)chroman-2,4-dione. Crystal structure of the 3-(1-(3-hydroxypropylamino)ethylidene)-chroman-2,4-dione
2017
Autori:
Avdović, Edina H.Stojković, Danijela L.J.
Jevtić, Verica V.
Kosić, Milica
Ristić, Biljana
Harhaji-Trajković, Ljubica
Vukić, Milena
Vuković, Nenad
Marković, Zoran S.
Potočňák, Ivan
Trifunović, Srećko R.
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2017 Elsevier B.V.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The new coumarine derivative, 3-(1-(3-hydroxypropylamino)ethylidene)chroman-2,4-dione, and corresponding palladium(II) complex have been synthesized and characterized by microanalysis, infrared, 1H and 13C NMR spectroscopy. The structure of the ligand, solved using a monocrystal X-ray structural analysis, consists of two crystallographic different pseudocentrosymmetrically related molecules of 3-(1-(3-hydroxypropylamino)ethylidene)chroman-2,4-dione, while the structure of the square-planar palladium(II) complex was proposed on the basis of DFT calculations. The palladium(II) complex decreased viability of U251 human glioma and B16 mouse melanoma cells in a dose and time dependent manner, while its ligand exhibited only moderate cytotoxicity.
Ključne reči:
Coumarine-derived ligand; Palladium(II) complex; Cytotoxicity; Crystal structure; Apoptosis; Oxidative stressFinansiranje / projekti:
- Sinteza, modelovanje, fizičko-hemijske i biološke osobine organskih jedinjenja i odgovarajućih kompleksa metala (RS-MESTD-Basic Research (BR or ON)-172016)
- Preklinička ispitivanja bioaktivnih supstanci (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41010)
- Sinteza, karakterizacija i biološka ispitivanja steroidnih derivata i njihovih molekulskih agregata (RS-MESTD-Basic Research (BR or ON)-172021)
- Modulacija signalnih puteva koji kontrolišu intracelularni energetski balans u terapiji tumora i neuro-imuno-endokrinih poremećaja (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
- Uloga autofagije u regulaciji smrti tumorskih ćelija (RS-MESTD-Basic Research (BR or ON)-173053)
- Bilateral project between Republic of Serbia and Slovak Republic No. SK-SRB-2013-0004
- Project VEGA No. 1/0598/14
U:
- Inorganica Chimica Acta (2017), 466: 188-196
DOI: 10.1016/j.ica.2017.06.015
ISSN: 0020-1693
WoS: 000410683500024
Scopus: 2-s2.0-85020718781
URI
http://linkinghub.elsevier.com/retrieve/pii/S0020169317301597https://radar.ibiss.bg.ac.rs/handle/123456789/2792