Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes
2017
Authors:
Stojanović, Ivana D.Šavikin, Katarina
Nikolovski, Neda
Živković, Jelena
Saksida, Tamara
Momčilović, Miljana
Koprivica, Ivan
Vujičić, Milica
Stanisavljević, Suzana
Miljković, Đorđe
Menković, Nebojša
Document Type:
Article (Published version)
,
© 2017 Elsevier Ltd.
Metadata
Show full item recordAbstract:
Pomegranate peel extract (PPE) was obtained by aqueous-ethanol extraction and was abundant in punicalin, punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, effects of PPE were tested in vitro on immune cells and in animal models of multiple sclerosis and type 1 diabetes (T1D). In vitro, PPE inhibited interleukin-17 (IL-17) production from gut-associated lymphoid tissue (GALT) cells. PPE also reduced production of IL-17 in activated T cells isolated from animals with experimental autoimmune encephalomyelitis (EAE). It efficiently down-regulated clinical symptoms of EAE in DA rats and of streptozotocin-induced T1D in C57BL/6 mice. The effect of PPE in T1D was mediated by inhibition of immune cell infiltration into pancreatic islets and through interference with IL-17 and IFN-γ production in GALT. Our results suggest that PPE has the potential to be used as phytopharmaceutical for certain autoimmune and chronic inflammatory disorders.
Keywords:
Pomegranate; Type 1 diabetes; Multiple sclerosis; Interleukin-17; AutoimmunitySource:
Journal of Functional Foods, 2017, 35, 522-530Funding / projects:
- Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-MESTD-Basic Research (BR or ON)-173013)
- Traditional and new products of cultivated and wild growing fruits and grape vines, and by-products durring processing, with special emphasis on indigenous varieties: chemical characterization and biological profile (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46013)
- Cellular and molecular mechanisms of recovery of rats from experimental autoimmune encephalomyelitis (RS-MESTD-Basic Research (BR or ON)-173035)
DOI: 10.1016/j.jff.2017.06.021
ISSN: 1756-4646
WoS: 000406080900057
Scopus: 2-s2.0-85020768799
URI
http://linkinghub.elsevier.com/retrieve/pii/S1756464617303353https://radar.ibiss.bg.ac.rs/handle/123456789/2793