Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes
2017
Аутори:
Stojanović, Ivana D.Šavikin, Katarina
Nikolovski, Neda
Živković, Jelena
Saksida, Tamara
Momčilović, Miljana
Koprivica, Ivan
Vujičić, Milica
Stanisavljević, Suzana
Miljković, Đorđe
Menković, Nebojša
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2017 Elsevier Ltd.
Метаподаци
Приказ свих података о документуАпстракт:
Pomegranate peel extract (PPE) was obtained by aqueous-ethanol extraction and was abundant in punicalin, punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, effects of PPE were tested in vitro on immune cells and in animal models of multiple sclerosis and type 1 diabetes (T1D). In vitro, PPE inhibited interleukin-17 (IL-17) production from gut-associated lymphoid tissue (GALT) cells. PPE also reduced production of IL-17 in activated T cells isolated from animals with experimental autoimmune encephalomyelitis (EAE). It efficiently down-regulated clinical symptoms of EAE in DA rats and of streptozotocin-induced T1D in C57BL/6 mice. The effect of PPE in T1D was mediated by inhibition of immune cell infiltration into pancreatic islets and through interference with IL-17 and IFN-γ production in GALT. Our results suggest that PPE has the potential to be used as phytopharmaceutical for certain autoimmune and chronic inflammatory disorders.
Кључне речи:
Pomegranate; Type 1 diabetes; Multiple sclerosis; Interleukin-17; AutoimmunityИзвор:
Journal of Functional Foods, 2017, 35, 522-530Финансирање / пројекти:
- Молекуларни механизми физиолошке и фармаколошке контроле инфламације и канцера (RS-MESTD-Basic Research (BR or ON)-173013)
- Традиционални и нови производи од плодова гајених и самониклих врста воћака и винове лозе и нус-продуката у преради, са посебним освртом на аутохтоне сорте: хемијска карактеризација и биолошки профил (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46013)
- Ћелијски и молекулски механизми опоравка пацова од експерименталног аутоимунског енцефаломијелитиса (RS-MESTD-Basic Research (BR or ON)-173035)
DOI: 10.1016/j.jff.2017.06.021
ISSN: 1756-4646
WoS: 000406080900057
Scopus: 2-s2.0-85020768799
URI
http://linkinghub.elsevier.com/retrieve/pii/S1756464617303353https://radar.ibiss.bg.ac.rs/handle/123456789/2793