Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes
2017
Autori:
Stojanović, Ivana D.Šavikin, Katarina
Nikolovski, Neda
Živković, Jelena
Saksida, Tamara
Momčilović, Miljana
Koprivica, Ivan
Vujičić, Milica
Stanisavljević, Suzana
Miljković, Đorđe
Menković, Nebojša
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
,
© 2017 Elsevier Ltd.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Pomegranate peel extract (PPE) was obtained by aqueous-ethanol extraction and was abundant in punicalin, punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, effects of PPE were tested in vitro on immune cells and in animal models of multiple sclerosis and type 1 diabetes (T1D). In vitro, PPE inhibited interleukin-17 (IL-17) production from gut-associated lymphoid tissue (GALT) cells. PPE also reduced production of IL-17 in activated T cells isolated from animals with experimental autoimmune encephalomyelitis (EAE). It efficiently down-regulated clinical symptoms of EAE in DA rats and of streptozotocin-induced T1D in C57BL/6 mice. The effect of PPE in T1D was mediated by inhibition of immune cell infiltration into pancreatic islets and through interference with IL-17 and IFN-γ production in GALT. Our results suggest that PPE has the potential to be used as phytopharmaceutical for certain autoimmune and chronic inflammatory disorders.
Ključne reči:
Pomegranate; Type 1 diabetes; Multiple sclerosis; Interleukin-17; AutoimmunityIzvor:
Journal of Functional Foods, 2017, 35, 522-530Finansiranje / projekti:
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
- Tradicionalni i novi proizvodi od plodova gajenih i samoniklih vrsta voćaka i vinove loze i nus-produkata u preradi, sa posebnim osvrtom na autohtone sorte: hemijska karakterizacija i biološki profil (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46013)
- Ćelijski i molekulski mehanizmi oporavka pacova od eksperimentalnog autoimunskog encefalomijelitisa (RS-MESTD-Basic Research (BR or ON)-173035)
DOI: 10.1016/j.jff.2017.06.021
ISSN: 1756-4646
WoS: 000406080900057
Scopus: 2-s2.0-85020768799
URI
http://linkinghub.elsevier.com/retrieve/pii/S1756464617303353https://radar.ibiss.bg.ac.rs/handle/123456789/2793