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Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes
dc.creator | Stojanović, Ivana D. | |
dc.creator | Šavikin, Katarina | |
dc.creator | Nikolovski, Neda | |
dc.creator | Živković, Jelena | |
dc.creator | Saksida, Tamara | |
dc.creator | Momčilović, Miljana | |
dc.creator | Koprivica, Ivan | |
dc.creator | Vujičić, Milica | |
dc.creator | Stanisavljević, Suzana | |
dc.creator | Miljković, Đorđe | |
dc.creator | Menković, Nebojša | |
dc.date.accessioned | 2017-11-23T11:29:29Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.uri | http://linkinghub.elsevier.com/retrieve/pii/S1756464617303353 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/2793 | |
dc.description.abstract | Pomegranate peel extract (PPE) was obtained by aqueous-ethanol extraction and was abundant in punicalin, punicalagin and ellagic acid. As these compounds are known to act against inflammation and oxidative stress in synergistic fashion, effects of PPE were tested in vitro on immune cells and in animal models of multiple sclerosis and type 1 diabetes (T1D). In vitro, PPE inhibited interleukin-17 (IL-17) production from gut-associated lymphoid tissue (GALT) cells. PPE also reduced production of IL-17 in activated T cells isolated from animals with experimental autoimmune encephalomyelitis (EAE). It efficiently down-regulated clinical symptoms of EAE in DA rats and of streptozotocin-induced T1D in C57BL/6 mice. The effect of PPE in T1D was mediated by inhibition of immune cell infiltration into pancreatic islets and through interference with IL-17 and IFN-γ production in GALT. Our results suggest that PPE has the potential to be used as phytopharmaceutical for certain autoimmune and chronic inflammatory disorders. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46013/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Functional Foods | |
dc.subject | Pomegranate | |
dc.subject | Type 1 diabetes | |
dc.subject | Multiple sclerosis | |
dc.subject | Interleukin-17 | |
dc.subject | Autoimmunity | |
dc.title | Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Шавикин, Катарина; Момчиловић, Миљана; Стојановић, Ивана; Станисављевић, Сузана; Вујичић, Милица; Саксида, Тамара; Менковић, Небојша; Копривица, Иван; Живковић, Јелена; Миљковић, Ђорђе; Ђедовић, Неда; | |
dc.rights.holder | © 2017 Elsevier Ltd. | |
dc.citation.volume | 35 | |
dc.identifier.doi | 10.1016/j.jff.2017.06.021 | |
dc.identifier.scopus | 2-s2.0-85020768799 | |
dc.identifier.wos | 000406080900057 | |
dc.citation.apa | Stojanović, I., Šavikin, K., Đedović, N., Živković, J., Saksida, T., Momčilović, M., Koprivica, I., et al. (2017). Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes. Journal of Functional Foods, 35, 522–530. | |
dc.citation.vancouver | Stojanović I, Šavikin K, Đedović N, Živković J, Saksida T, Momčilović M, Koprivica I, Vujičić M, Stanisavljević S, Miljković Đ, Menković N. Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes. J Funct Foods. 2017;35:522–30. | |
dc.citation.spage | 522 | |
dc.citation.epage | 530 | |
dc.type.version | publishedVersion | en |
dc.citation.rank | aM21 |