Genetic predictors of celiac disease, lactose intolerance, and vitamin D function and presence of peptide morphins in urine of children with neurodevelopmental disorders
2019
Аутори:
Bojović, KatarinaStanković, Biljana
Kotur, Nikola
Krstić Milošević, Dijana
Gašić, Vladimir
Pavlović, Sonja
Zukić, Branka
Ignjatović, Đurđica
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2017 Informa UK Limited, trading as Taylor & Francis Group
Метаподаци
Приказ свих података о документуАпстракт:
Gastrointestinal disturbances, nutritional deficiencies, and food intolerances are frequently observed in children with neurodevelopmental disorders (NDD). To reveal possible association of celiac disease risk variants (HLA-DQ), lactose intolerance associated variant (LCT-13910C > T) as well as variant associated with vitamin D function (VDR FokI) with NDD, polymerase chain reaction-based methodology was used. Additionally, intestinal peptide permeability was estimated in NDD patients and healthy children by measuring the level of peptides in urine using high-performance liquid chromatography. Levels of opioid peptides, casomorphin 8, and gluten exorphin C were significantly elevated in urine samples of NDD patients (P = 0.004 and P = 0.005, respectively), but no association of genetic risk variants for celiac disease and lactose intolerance with NDD was found. Our results indicate that increased intestinal peptide permeability observed in analyzed NDD patients is not associated with genetic predictors of celiac disease or lactose intolerance. We have also found that FF genotype of VDR FokI and lower serum levels of vitamin D (25-OH) showed association with childhood autism (CHA), a subgroup of NDD. We hypothesize that vitamin D might be important for the development of CHA.
Кључне речи:
Autism; Exorphin; Food intolerance; Leaky gut; VDR geneИзвор:
Nutritional Neuroscience, 2019, 22, 1, 40-50
DOI: 10.1080/1028415X.2017.1352121
ISSN: 1028-415X
PubMed: 28738753
WoS: 000451823500004
Scopus: 2-s2.0-85025839558
URI
https://www.tandfonline.com/doi/full/10.1080/1028415X.2017.1352121https://radar.ibiss.bg.ac.rs/handle/123456789/2823